Detailed information of TA system TA048791

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4049358..4050031
• Replicon: chromosome
• Accession: NZ_CP009360
• Organism: Mycobacterium avium subsp. hominissuis strain OCU464

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A2A2ZF02
• Locus tag: KV38_RS18820
• Protein ID: WP_033718548.1
• Coordinates: 4049358..4049705 (+)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A2A2ZDH9
• Locus tag: KV38_RS18825
• Protein ID: WP_033718509.1
• Coordinates: 4049702..4050031 (+)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KV38_RS18795	4044955..4045380	+	426	WP_129560155.1	hypothetical protein	-
KV38_RS18800	4045425..4046584	+	1160	WP_085989675.1	IS3 family transposase	-
KV38_RS18805	4046972..4047820	+	849	WP_076221054.1	helix-turn-helix domain-containing protein	-
KV38_RS18810	4047792..4047980	+	189	WP_062886189.1	helix-turn-helix domain-containing protein	-
KV38_RS18815	4047977..4049305	+	1329	WP_116671117.1	site-specific integrase	-
KV38_RS18820	4049358..4049705	+	348	WP_033718548.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KV38_RS18825	4049702..4050031	+	330	WP_033718509.1	helix-turn-helix transcriptional regulator	Antitoxin
KV38_RS18830	4050233..4050835	+	603	WP_129560154.1	hypothetical protein	-
KV38_RS18835	4050832..4051284	+	453	WP_033718506.1	GNAT family N-acetyltransferase	-
KV38_RS18840	4051349..4051972	+	624	Protein_3721	hypothetical protein	-
KV38_RS18845	4052163..4053701	+	1539	WP_062887722.1	IS21 family transposase	-
KV38_RS18850	4053765..4054520	+	756	WP_062887723.1	IS21-like element helper ATPase IstB	-
KV38_RS18855	4054616..4054852	+	237	Protein_3724	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	4042788..4058688	15900
	-	flank	IS/Tn	-	-	4053765..4054520	755

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-94)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 12988.78 Da
• Isoelectric Point: 4.3961

>T48791 WP_033718548.1 NZ_CP009360:4049358-4049705 [Mycobacterium avium subsp. hominissuis]
MSWDVILLEEVETWYFSLDEDAMAAVTGAIDLLELEGPTLGRPTVDKVKGSKFHSMKELRPAGTSIRILFIFDPRRQAIL
LLGGDKAGNWKSWYDKNIPIAERSYEDWLATEGGE

Nucleotide

• Length: 348 bp

>T48791 NZ_CP009360:4049358-4049705 [Mycobacterium avium subsp. hominissuis]
ATGTCCTGGGATGTGATCCTGCTGGAGGAGGTCGAAACCTGGTACTTCTCGCTCGACGAAGACGCGATGGCAGCGGTCAC
CGGGGCCATCGACCTGCTCGAGCTGGAAGGACCAACGCTAGGCCGGCCGACGGTGGACAAGGTCAAGGGATCGAAGTTCC
ACAGCATGAAGGAGCTACGGCCAGCCGGCACCAGCATCCGGATCCTGTTCATCTTCGATCCGCGGCGTCAAGCGATCCTA
TTGCTCGGCGGGGACAAGGCAGGCAACTGGAAAAGCTGGTACGACAAGAACATTCCGATAGCTGAGCGAAGCTACGAGGA
CTGGCTCGCGACTGAGGGAGGTGAATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11922.43 Da
• Isoelectric Point: 7.4050

>AT48791 WP_033718509.1 NZ_CP009360:4049702-4050031 [Mycobacterium avium subsp. hominissuis]
MSMARNWRDIRADAIAQGRLDPARADAARNEMHDAVQAHRLAEIRKAQGHRRQADVAVLMGVSQARVSKLESGDLSHTEL
GTLQSYVAALGGSLRVVAEFDEKTVELTT

Nucleotide

• Length: 330 bp

>AT48791 NZ_CP009360:4049702-4050031 [Mycobacterium avium subsp. hominissuis]
ATGAGCATGGCACGCAACTGGCGTGATATCCGTGCCGACGCCATCGCGCAGGGGCGCCTGGACCCCGCCCGCGCCGATGC
CGCGCGCAACGAGATGCACGACGCGGTCCAGGCCCACCGGCTCGCCGAAATTCGCAAAGCCCAAGGCCACAGACGTCAGG
CCGACGTCGCTGTCCTGATGGGGGTTTCGCAAGCGCGAGTGTCGAAGTTGGAGAGCGGCGACCTGTCGCACACCGAGCTT
GGCACGCTCCAGTCTTACGTGGCGGCGTTGGGCGGCAGCCTCCGGGTCGTCGCCGAGTTTGACGAGAAGACCGTGGAGCT
GACAACTTGA

Structures

Toxin

• AlphaFold DB: A0A2A2ZF02

Antitoxin

• AlphaFold DB: A0A2A2ZDH9