Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4049358..4050031 Replicon chromosome
Accession NZ_CP009360
Organism Mycobacterium avium subsp. hominissuis strain OCU464

Toxin (Protein)


Gene name higB Uniprot ID A0A2A2ZF02
Locus tag KV38_RS18820 Protein ID WP_033718548.1
Coordinates 4049358..4049705 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2A2ZDH9
Locus tag KV38_RS18825 Protein ID WP_033718509.1
Coordinates 4049702..4050031 (+) Length 110 a.a.

Genomic Context

KV38_RS18795KV38_RS18800KV38_RS18805KV38_RS18810KV38_RS18815KV38_RS18820KV38_RS18825KV38_RS18830KV38_RS18835KV38_RS18840KV38_RS18845KV38_RS18850KV38_RS18855
Location: 4044955..4045380 (426 bp)
Type: Others
Protein ID: WP_129560155.1
Location: 4045425..4046584 (1160 bp)
Type: Others
Protein ID: WP_085989675.1
Location: 4046972..4047820 (849 bp)
Type: Others
Protein ID: WP_076221054.1
Location: 4047792..4047980 (189 bp)
Type: Others
Protein ID: WP_062886189.1
Location: 4047977..4049305 (1329 bp)
Type: Others
Protein ID: WP_116671117.1
Location: 4049358..4049705 (348 bp)
Type: Toxin
Protein ID: WP_033718548.1
Location: 4049702..4050031 (330 bp)
Type: Antitoxin
Protein ID: WP_033718509.1
Location: 4050233..4050835 (603 bp)
Type: Others
Protein ID: WP_129560154.1
Location: 4050832..4051284 (453 bp)
Type: Others
Protein ID: WP_033718506.1
Location: 4051349..4051972 (624 bp)
Type: Others
Protein ID: Protein_3721
Location: 4052163..4053701 (1539 bp)
Type: Others
Protein ID: WP_062887722.1
Location: 4053765..4054520 (756 bp)
Type: Others
Protein ID: WP_062887723.1
Location: 4054616..4054852 (237 bp)
Type: Others
Protein ID: Protein_3724
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KV38_RS187954044955..4045380+426WP_129560155.1hypothetical protein-
KV38_RS188004045425..4046584+1160WP_085989675.1IS3 family transposase-
KV38_RS188054046972..4047820+849WP_076221054.1helix-turn-helix domain-containing protein-
KV38_RS188104047792..4047980+189WP_062886189.1helix-turn-helix domain-containing protein-
KV38_RS188154047977..4049305+1329WP_116671117.1site-specific integrase-
KV38_RS188204049358..4049705+348WP_033718548.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KV38_RS188254049702..4050031+330WP_033718509.1helix-turn-helix transcriptional regulatorAntitoxin
KV38_RS188304050233..4050835+603WP_129560154.1hypothetical protein-
KV38_RS188354050832..4051284+453WP_033718506.1GNAT family N-acetyltransferase-
KV38_RS188404051349..4051972+624Protein_3721hypothetical protein-
KV38_RS188454052163..4053701+1539WP_062887722.1IS21 family transposase-
KV38_RS188504053765..4054520+756WP_062887723.1IS21-like element helper ATPase IstB-
KV38_RS188554054616..4054852+237Protein_3724hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--4042788..405868815900
-flankIS/Tn--4053765..4054520755


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-94)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12988.78 Da        Isoelectric Point: 4.3961

>T48791 WP_033718548.1 NZ_CP009360:4049358-4049705 [Mycobacterium avium subsp. hominissuis]
MSWDVILLEEVETWYFSLDEDAMAAVTGAIDLLELEGPTLGRPTVDKVKGSKFHSMKELRPAGTSIRILFIFDPRRQAIL
LLGGDKAGNWKSWYDKNIPIAERSYEDWLATEGGE

Download         Length: 348 bp

>T48791 NZ_CP009360:4049358-4049705 [Mycobacterium avium subsp. hominissuis]
ATGTCCTGGGATGTGATCCTGCTGGAGGAGGTCGAAACCTGGTACTTCTCGCTCGACGAAGACGCGATGGCAGCGGTCAC
CGGGGCCATCGACCTGCTCGAGCTGGAAGGACCAACGCTAGGCCGGCCGACGGTGGACAAGGTCAAGGGATCGAAGTTCC
ACAGCATGAAGGAGCTACGGCCAGCCGGCACCAGCATCCGGATCCTGTTCATCTTCGATCCGCGGCGTCAAGCGATCCTA
TTGCTCGGCGGGGACAAGGCAGGCAACTGGAAAAGCTGGTACGACAAGAACATTCCGATAGCTGAGCGAAGCTACGAGGA
CTGGCTCGCGACTGAGGGAGGTGAATGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11922.43 Da        Isoelectric Point: 7.4050

>AT48791 WP_033718509.1 NZ_CP009360:4049702-4050031 [Mycobacterium avium subsp. hominissuis]
MSMARNWRDIRADAIAQGRLDPARADAARNEMHDAVQAHRLAEIRKAQGHRRQADVAVLMGVSQARVSKLESGDLSHTEL
GTLQSYVAALGGSLRVVAEFDEKTVELTT

Download         Length: 330 bp

>AT48791 NZ_CP009360:4049702-4050031 [Mycobacterium avium subsp. hominissuis]
ATGAGCATGGCACGCAACTGGCGTGATATCCGTGCCGACGCCATCGCGCAGGGGCGCCTGGACCCCGCCCGCGCCGATGC
CGCGCGCAACGAGATGCACGACGCGGTCCAGGCCCACCGGCTCGCCGAAATTCGCAAAGCCCAAGGCCACAGACGTCAGG
CCGACGTCGCTGTCCTGATGGGGGTTTCGCAAGCGCGAGTGTCGAAGTTGGAGAGCGGCGACCTGTCGCACACCGAGCTT
GGCACGCTCCAGTCTTACGTGGCGGCGTTGGGCGGCAGCCTCCGGGTCGTCGCCGAGTTTGACGAGAAGACCGTGGAGCT
GACAACTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2A2ZF02

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A2A2ZDH9

References