Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1237387..1238007 Replicon chromosome
Accession NZ_CP009322
Organism Burkholderia gladioli strain ATCC 10248

Toxin (Protein)


Gene name higB Uniprot ID A0A808W391
Locus tag BM43_RS06040 Protein ID WP_036056413.1
Coordinates 1237729..1238007 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A808W2D6
Locus tag BM43_RS06035 Protein ID WP_036056415.1
Coordinates 1237387..1237710 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BM43_RS06015 1233102..1233515 - 414 WP_013690200.1 MarR family transcriptional regulator -
BM43_RS06020 1233623..1234801 - 1179 WP_036056422.1 HPP family protein -
BM43_RS06025 1235195..1236151 + 957 WP_036056420.1 LysR family transcriptional regulator -
BM43_RS06030 1236194..1237279 - 1086 WP_036056417.1 ionic transporter y4hA -
BM43_RS06035 1237387..1237710 - 324 WP_036056415.1 HigA family addiction module antidote protein Antitoxin
BM43_RS06040 1237729..1238007 - 279 WP_036056413.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BM43_RS06045 1238250..1238918 + 669 WP_025100406.1 NAAT family transporter -
BM43_RS06050 1239036..1239905 - 870 WP_036056411.1 CPBP family intramembrane metalloprotease -
BM43_RS06055 1240179..1240901 - 723 WP_013690208.1 fumarylacetoacetate hydrolase family protein -
BM43_RS06060 1241050..1242150 - 1101 WP_036056409.1 helix-turn-helix transcriptional regulator -
BM43_RS06065 1242343..1242945 - 603 WP_036056407.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(25-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(11-91)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10301.87 Da        Isoelectric Point: 9.2604

>T48765 WP_036056413.1 NZ_CP009322:c1238007-1237729 [Burkholderia gladioli]
MIQSFRCKRTAALFAGESPPAWGAVAQVARRKLAMLDAAQALRDLAVPPGNQLEGLFGDRAGQYSIRINERWRLCFVWSS
RGPELVEIVDYH

Download         Length: 279 bp

>T48765 NZ_CP009322:c1238007-1237729 [Burkholderia gladioli]
ATGATCCAGTCATTCCGATGCAAGCGCACCGCCGCGCTGTTCGCCGGCGAATCGCCGCCGGCCTGGGGTGCCGTGGCACA
AGTGGCCCGGCGCAAGCTGGCCATGCTCGATGCGGCCCAGGCGCTGCGCGACCTGGCCGTGCCGCCCGGCAACCAACTCG
AAGGCCTGTTCGGCGATCGCGCGGGGCAATACAGCATCCGGATCAACGAGCGCTGGCGCCTTTGTTTCGTCTGGAGCAGC
CGGGGGCCCGAGCTCGTCGAGATCGTCGATTACCACTGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11906.72 Da        Isoelectric Point: 7.2024

>AT48765 WP_036056415.1 NZ_CP009322:c1237710-1237387 [Burkholderia gladioli]
MNAKSVKPVNAMPAIHPGEILREEFLVPLALSVNALSLALMVPATRMHEIVNERRGITADTAYRLSRYFGTTPEFWLALQ
ADYDIKTLPNRDEIDRKVDARSTGAAP

Download         Length: 324 bp

>AT48765 NZ_CP009322:c1237710-1237387 [Burkholderia gladioli]
ATGAATGCCAAGAGTGTGAAGCCCGTCAACGCGATGCCCGCCATCCACCCCGGCGAAATCCTGCGCGAGGAGTTCCTGGT
GCCGCTCGCGCTCAGCGTCAACGCGCTGTCGCTGGCGCTGATGGTGCCGGCCACCCGCATGCACGAGATCGTCAACGAGC
GGCGCGGCATCACCGCCGACACGGCCTACCGCCTGTCGCGCTACTTCGGCACCACGCCGGAGTTCTGGCTGGCCCTGCAG
GCCGACTACGACATCAAGACCCTGCCGAACCGCGACGAGATCGACCGCAAGGTCGATGCGCGCTCCACCGGCGCGGCGCC
CTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808W391

Antitoxin

Source ID Structure
AlphaFold DB A0A808W2D6

References