Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 2082692..2083194 | Replicon | chromosome |
| Accession | NZ_CP009273 | ||
| Organism | Escherichia coli BW25113 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | BW25113_RS10540 | Protein ID | WP_000767829.1 |
| Coordinates | 2082692..2082946 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | BW25113_RS10545 | Protein ID | WP_001259255.1 |
| Coordinates | 2082943..2083194 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BW25113_RS10515 (BW25113_2012) | 2077707..2077934 | - | 228 | WP_000234896.1 | sulfurtransferase TusA | - |
| BW25113_RS10520 (BW25113_2013) | 2077948..2079006 | - | 1059 | WP_000492339.1 | transport protein YeeE | - |
| BW25113_RS10525 (BW25113_2014) | 2079185..2080543 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| BW25113_RS25670 (BW25113_4678) | 2080533..2080595 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| BW25113_RS10530 (BW25113_2015) | 2080810..2081739 | - | 930 | WP_000803351.1 | LysR family transcriptional regulator | - |
| BW25113_RS10535 (BW25113_2016) | 2081785..2082609 | - | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| BW25113_RS10540 (BW25113_4539) | 2082692..2082946 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| BW25113_RS10545 (BW25113_2017) | 2082943..2083194 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| BW25113_RS24020 (BW25113_2018) | 2083477..2083527 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| BW25113_RS10550 (BW25113_2019) | 2083673..2084572 | + | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| BW25113_RS10555 (BW25113_2020) | 2084578..2085882 | + | 1305 | WP_000009594.1 | histidinol dehydrogenase | - |
| BW25113_RS10560 (BW25113_2021) | 2085879..2086949 | + | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| BW25113_RS10565 (BW25113_2022) | 2086949..2088016 | + | 1068 | WP_000080105.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T48693 WP_000767829.1 NZ_CP009273:c2082946-2082692 [Escherichia coli BW25113]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T48693 NZ_CP009273:c2082946-2082692 [Escherichia coli BW25113]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT48693 WP_001259255.1 NZ_CP009273:c2083194-2082943 [Escherichia coli BW25113]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT48693 NZ_CP009273:c2083194-2082943 [Escherichia coli BW25113]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|