Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 1265159..1265381 Replicon chromosome
Accession NZ_CP009273
Organism Escherichia coli BW25113

Toxin (Protein)


Gene name ldrD Uniprot ID J7R083
Locus tag BW25113_RS06335 Protein ID WP_000170963.1
Coordinates 1265159..1265266 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 1265314..1265381 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BW25113_RS06305 (BW25113_1211) 1260468..1261550 + 1083 WP_000804726.1 peptide chain release factor 1 -
BW25113_RS06310 (BW25113_1212) 1261550..1262383 + 834 WP_000456467.1 peptide chain release factor N(5)-glutamine methyltransferase -
BW25113_RS06315 (BW25113_1213) 1262380..1262772 + 393 WP_000200374.1 invasion regulator SirB2 -
BW25113_RS06320 (BW25113_1214) 1262776..1263585 + 810 WP_001257044.1 invasion regulator SirB1 -
BW25113_RS06325 (BW25113_1215) 1263621..1264475 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
BW25113_RS06330 (BW25113_4419) 1264624..1264731 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
BW25113_RS06335 (BW25113_4421) 1265159..1265266 - 108 WP_000170963.1 small toxic polypeptide LdrB Toxin
- 1265314..1265381 + 68 - - Antitoxin
BW25113_RS06340 (BW25113_4423) 1265694..1265801 - 108 WP_000170955.1 small toxic polypeptide LdrA/LdrC -
BW25113_RS06345 (BW25113_1216) 1266205..1267305 - 1101 WP_000063607.1 sodium-potassium/proton antiporter ChaA -
BW25113_RS06350 (BW25113_1217) 1267575..1267805 + 231 WP_001146444.1 putative cation transport regulator ChaB -
BW25113_RS06355 (BW25113_1218) 1267963..1268658 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
BW25113_RS06360 (BW25113_1219) 1268702..1269055 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3971.74 Da        Isoelectric Point: 11.4779

>T48671 WP_000170963.1 NZ_CP009273:c1265266-1265159 [Escherichia coli BW25113]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Download         Length: 108 bp

>T48671 NZ_CP009273:c1265266-1265159 [Escherichia coli BW25113]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 68 bp

>AT48671 NZ_CP009273:1265314-1265381 [Escherichia coli BW25113]
GTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References