Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-MqsA |
| Location | 1839069..1839702 | Replicon | chromosome |
| Accession | NZ_CP009261 | ||
| Organism | Vibrio vulnificus strain 93U204 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A347UQS4 |
| Locus tag | VV93_RS08605 | Protein ID | WP_012600340.1 |
| Coordinates | 1839370..1839702 (-) | Length | 111 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | VV93_RS08600 | Protein ID | WP_017049537.1 |
| Coordinates | 1839069..1839383 (-) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| VV93_RS23500 | 1834148..1834297 | - | 150 | WP_080726412.1 | DUF3265 domain-containing protein | - |
| VV93_RS08575 | 1834294..1834809 | - | 516 | WP_039553866.1 | GNAT family N-acetyltransferase | - |
| VV93_RS08590 | 1836064..1836456 | - | 393 | WP_011080347.1 | hypothetical protein | - |
| VV93_RS08595 | 1836662..1837630 | + | 969 | WP_080726343.1 | IS30-like element ISVa6 family transposase | - |
| VV93_RS23510 | 1838001..1838129 | - | 129 | WP_080726410.1 | DUF3265 domain-containing protein | - |
| VV93_RS23515 | 1838474..1838614 | - | 141 | WP_080726361.1 | DUF3265 domain-containing protein | - |
| VV93_RS23520 | 1838962..1839054 | - | 93 | WP_005445734.1 | DUF3265 domain-containing protein | - |
| VV93_RS08600 | 1839069..1839383 | - | 315 | WP_017049537.1 | DNA-binding transcriptional regulator | Antitoxin |
| VV93_RS08605 | 1839370..1839702 | - | 333 | WP_012600340.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| VV93_RS23525 | 1839740..1839916 | - | 177 | WP_080726362.1 | DUF3265 domain-containing protein | - |
| VV93_RS24145 | 1840261..1840389 | - | 129 | WP_103277396.1 | DUF3265 domain-containing protein | - |
| VV93_RS23535 | 1840727..1840855 | - | 129 | WP_080726413.1 | DUF3265 domain-containing protein | - |
| VV93_RS08610 | 1840864..1841370 | - | 507 | WP_039555194.1 | AAA family ATPase | - |
| VV93_RS23540 | 1841367..1841528 | - | 162 | WP_080726364.1 | DUF3265 domain-containing protein | - |
| VV93_RS08615 | 1841510..1841941 | - | 432 | WP_039553784.1 | hypothetical protein | - |
| VV93_RS23545 | 1841959..1842081 | - | 123 | WP_080726414.1 | DUF3265 domain-containing protein | - |
| VV93_RS08620 | 1842092..1842481 | - | 390 | WP_039553875.1 | VOC family protein | - |
| VV93_RS23550 | 1842541..1842724 | - | 184 | Protein_1700 | DUF3265 domain-containing protein | - |
| VV93_RS23560 | 1843037..1843165 | - | 129 | WP_080726415.1 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1785871..1855409 | 69538 | |
| - | flank | IS/Tn | - | - | 1844137..1845105 | 968 | |
| - | inside | Integron | - | - | 1790432..1855409 | 64977 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 111 a.a. Molecular weight: 12906.76 Da Isoelectric Point: 10.0960
>T48662 WP_012600340.1 NZ_CP009261:c1839702-1839370 [Vibrio vulnificus]
MKSVFVESTIFEKYRNEYLSDDEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS
MKSVFVESTIFEKYRNEYLSDDEFRLFQAELMSNPKQGDVIQGTGGLRKIRVASKGKGKRGGSRVIYYFLDEKRRFYLLT
IYGKNEMSDLTADQKKQLKAFMEAWRNEQS
Download Length: 333 bp
>T48662 NZ_CP009261:c1839702-1839370 [Vibrio vulnificus]
ATGAAAAGTGTATTTGTCGAATCAACCATATTTGAAAAGTACCGTAATGAATATCTCAGCGATGATGAGTTTAGGCTTTT
TCAAGCAGAGTTAATGTCTAACCCGAAGCAGGGTGACGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGTGGCGGCTCTCGCGTTATCTATTACTTCCTCGATGAGAAGCGTCGTTTCTACTTGCTGACG
ATTTACGGCAAGAATGAAATGTCCGACTTAACCGCAGACCAAAAGAAACAACTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAATCGTGA
ATGAAAAGTGTATTTGTCGAATCAACCATATTTGAAAAGTACCGTAATGAATATCTCAGCGATGATGAGTTTAGGCTTTT
TCAAGCAGAGTTAATGTCTAACCCGAAGCAGGGTGACGTGATTCAAGGTACAGGTGGTTTGCGAAAGATTCGAGTTGCAA
GTAAAGGTAAGGGCAAGCGTGGCGGCTCTCGCGTTATCTATTACTTCCTCGATGAGAAGCGTCGTTTCTACTTGCTGACG
ATTTACGGCAAGAATGAAATGTCCGACTTAACCGCAGACCAAAAGAAACAACTAAAGGCTTTTATGGAGGCGTGGCGTAA
TGAGCAATCGTGA
Antitoxin
Download Length: 105 a.a. Molecular weight: 11704.17 Da Isoelectric Point: 6.3290
>AT48662 WP_017049537.1 NZ_CP009261:c1839383-1839069 [Vibrio vulnificus]
MSNRDLFAELSSALVEAKEHSEGKLTLKTHQVNDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL
MSNRDLFAELSSALVEAKEHSEGKLTLKTHQVNDISELNISPDEIVSIREQFNMSRGVFARLLHTSSRTLENWEQGRSAP
NGQAVTLLKLVQRHPETLSHIAEL
Download Length: 315 bp
>AT48662 NZ_CP009261:c1839383-1839069 [Vibrio vulnificus]
ATGAGCAATCGTGATCTATTTGCGGAGTTAAGTTCAGCACTTGTTGAGGCTAAAGAGCATTCAGAGGGCAAGCTTACCCT
TAAAACTCATCAAGTTAACGACATCAGTGAGTTAAATATCTCACCTGATGAAATCGTGAGTATTCGAGAACAGTTTAATA
TGTCTCGTGGTGTATTTGCTCGTTTGTTGCACACATCATCTCGTACGTTAGAAAACTGGGAACAAGGTCGTAGCGCACCA
AATGGACAAGCAGTAACCCTTCTAAAGCTGGTTCAGCGTCATCCAGAGACCCTGTCGCACATCGCTGAGCTATAA
ATGAGCAATCGTGATCTATTTGCGGAGTTAAGTTCAGCACTTGTTGAGGCTAAAGAGCATTCAGAGGGCAAGCTTACCCT
TAAAACTCATCAAGTTAACGACATCAGTGAGTTAAATATCTCACCTGATGAAATCGTGAGTATTCGAGAACAGTTTAATA
TGTCTCGTGGTGTATTTGCTCGTTTGTTGCACACATCATCTCGTACGTTAGAAAACTGGGAACAAGGTCGTAGCGCACCA
AATGGACAAGCAGTAACCCTTCTAAAGCTGGTTCAGCGTCATCCAGAGACCCTGTCGCACATCGCTGAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|