Detailed information of TA system TA048646

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 1168161..1168666
• Replicon: chromosome
• Accession: NZ_CP009246
• Organism: Corynebacterium flavescens strain OJ8

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: CFLV_RS05455
• Protein ID: WP_075729684.1
• Coordinates: 1168161..1168415 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: CFLV_RS05460
• Protein ID: WP_075729685.1
• Coordinates: 1168415..1168666 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CFLV_RS05425	1163452..1164093	+	642	WP_075729680.1	DNA polymerase III subunit epsilon	-
CFLV_RS05430	1164143..1164952	+	810	WP_174775500.1	fumarylacetoacetate hydrolase family protein	-
CFLV_RS05435	1164967..1166070	-	1104	WP_075729682.1	isochorismate synthase	-
CFLV_RS05440	1166182..1167672	+	1491	WP_075729683.1	glutamate--tRNA ligase	-
CFLV_RS05455	1168161..1168415	-	255	WP_075729684.1	Txe/YoeB family addiction module toxin	Toxin
CFLV_RS05460	1168415..1168666	-	252	WP_075729685.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CFLV_RS05465	1168769..1169884	-	1116	WP_075729686.1	hypothetical protein	-
CFLV_RS05470	1169881..1173234	-	3354	WP_075729687.1	ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-70)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10115.62 Da
• Isoelectric Point: 8.0396

>T48646 WP_075729684.1 NZ_CP009246:c1168415-1168161 [Corynebacterium flavescens]
MRLVWDKSAWEDYKHWQTIDRRILKRINTLIDACLREPFEGIGKPEELKYGAQGAWSRRITDEHRLVYLVAGEDLIILQA
RYHY

Nucleotide

• Length: 255 bp

>T48646 NZ_CP009246:c1168415-1168161 [Corynebacterium flavescens]
ATGCGTCTCGTCTGGGACAAGTCGGCGTGGGAGGACTATAAGCATTGGCAAACCATTGATCGGCGCATACTAAAACGCAT
CAACACCCTGATCGATGCATGCCTGCGCGAACCTTTCGAAGGCATTGGAAAGCCCGAGGAACTCAAGTACGGCGCACAAG
GGGCGTGGTCACGGCGGATCACCGATGAACACCGCCTGGTCTATCTAGTCGCTGGAGAAGATCTCATCATTCTTCAGGCC
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9465.56 Da
• Isoelectric Point: 4.8483

>AT48646 WP_075729685.1 NZ_CP009246:c1168666-1168415 [Corynebacterium flavescens]
MSITASEARRTLFPLIERINADRDAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPANARRLLDSYERARAGAVQEHELD
RDE

Nucleotide

• Length: 252 bp

>AT48646 NZ_CP009246:c1168666-1168415 [Corynebacterium flavescens]
ATGTCCATCACCGCAAGTGAAGCCCGGAGGACGCTCTTTCCATTGATCGAGCGAATCAACGCCGATCGGGACGCAGTGGA
GATCGTTTCTCGCAAAGGCAATGCCGTTTTGATGCCCGCCGACGAGTACGCAGCGTGGCAGGAGACGGCCTATCTATTCC
GTTCTCCGGCAAATGCGCGCAGGCTGCTTGATTCCTATGAGCGTGCACGCGCAGGCGCGGTCCAGGAGCACGAGCTTGAC
CGAGACGAATAA