Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 158290..158933 Replicon chromosome
Accession NZ_CP009237
Organism Glaesserella parasuis strain KL0318

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JT17_RS00950 Protein ID WP_021109713.1
Coordinates 158290..158634 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JT17_RS00955 Protein ID WP_035519504.1
Coordinates 158637..158933 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JT17_RS00940 154894..155985 - 1092 WP_005714201.1 murein transglycosylase A -
JT17_RS00945 156096..158075 - 1980 WP_021109714.1 exoribonuclease II -
JT17_RS00950 158290..158634 + 345 WP_021109713.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JT17_RS00955 158637..158933 + 297 WP_035519504.1 helix-turn-helix domain-containing protein Antitoxin
JT17_RS00960 158990..159952 + 963 WP_044008955.1 WYL domain-containing protein -
JT17_RS00965 160028..160801 + 774 WP_035519505.1 PD-(D/E)XK nuclease family protein -
JT17_RS00970 160818..161465 + 648 WP_016527812.1 hypothetical protein -
JT17_RS00975 161744..162460 + 717 WP_035519506.1 hypothetical protein -
JT17_RS00980 162505..163474 + 970 Protein_196 transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(47-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13262.28 Da        Isoelectric Point: 7.9640

>T48577 WP_021109713.1 NZ_CP009237:158290-158634 [Glaesserella parasuis]
METEEYLTFIKTKVFEEDRKALMSDDEYQKFQAYLLESHELGDFIQNTGGCQKIRWKLESNNKGKSGGVRVIYYVVTKQG
KLLLMMMYAKSKQDNMSDKQKAMLKAVVSQLSEE

Download         Length: 345 bp

>T48577 NZ_CP009237:158290-158634 [Glaesserella parasuis]
ATGGAAACAGAAGAATATCTTACTTTTATTAAAACCAAAGTTTTTGAAGAAGACCGAAAAGCATTAATGTCTGATGATGA
ATATCAGAAATTTCAGGCTTATTTATTAGAATCTCACGAATTAGGCGATTTTATTCAGAATACTGGTGGTTGCCAAAAAA
TTCGCTGGAAACTAGAAAGTAATAACAAGGGCAAAAGTGGTGGTGTAAGGGTGATTTACTATGTTGTAACCAAACAGGGA
AAATTATTATTAATGATGATGTATGCTAAAAGCAAACAAGACAATATGAGTGATAAACAAAAAGCAATGTTAAAAGCGGT
TGTATCCCAATTAAGTGAGGAGTAA

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11206.15 Da        Isoelectric Point: 8.8246

>AT48577 WP_035519504.1 NZ_CP009237:158637-158933 [Glaesserella parasuis]
MEKELFERLMESAREMVAIEKGEIEVPPHRIHIHKIPNVKAIRTQHQMKQAEFAPLLGVSQNLVQSWEIGRRTPNGAARK
LLAIIEQQPELIPVLQGL

Download         Length: 297 bp

>AT48577 NZ_CP009237:158637-158933 [Glaesserella parasuis]
ATGGAAAAAGAACTTTTTGAACGTCTAATGGAAAGTGCGAGAGAAATGGTCGCCATTGAAAAAGGCGAAATAGAAGTACC
ACCGCATCGTATTCATATCCATAAAATCCCGAATGTCAAAGCGATTAGAACCCAGCACCAGATGAAACAAGCGGAATTTG
CTCCCCTTTTAGGCGTAAGCCAAAATCTTGTGCAGTCGTGGGAAATCGGCAGACGAACCCCAAATGGCGCTGCACGGAAA
TTGCTTGCGATTATTGAGCAACAGCCAGAACTTATCCCTGTATTACAAGGGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References