Detailed information of TA system TA048571

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-MqsA
• Location: 1812416..1813068
• Replicon: chromosome
• Accession: NZ_CP009230
• Organism: Aggregatibacter aphrophilus NJ8700

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: NJ8700_RS08420
• Protein ID: WP_005702038.1
• Coordinates: 1812721..1813068 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: NJ8700_RS08415
• Protein ID: WP_005702039.1
• Coordinates: 1812416..1812724 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NJ8700_RS08390	1808018..1808707	-	690	WP_005702044.1	50S ribosomal protein L1	-
NJ8700_RS08395	1808712..1809140	-	429	WP_005630840.1	50S ribosomal protein L11	-
NJ8700_RS08400	1809310..1809861	-	552	WP_005702043.1	transcription termination/antitermination protein NusG	-
NJ8700_RS08405	1809863..1810273	-	411	WP_005702041.1	preprotein translocase subunit SecE	-
NJ8700_RS08410	1811138..1811653	+	516	WP_005702040.1	Hcp family type VI secretion system effector	-
NJ8700_RS08415	1812416..1812724	-	309	WP_005702039.1	helix-turn-helix domain-containing protein	Antitoxin
NJ8700_RS08420	1812721..1813068	-	348	WP_005702038.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
NJ8700_RS08425	1813131..1813688	-	558	WP_005702037.1	hypothetical protein	-
NJ8700_RS08430	1813675..1813863	-	189	WP_005702035.1	hypothetical protein	-
NJ8700_RS08435	1813863..1814108	-	246	WP_005702034.1	hypothetical protein	-
NJ8700_RS08440	1814101..1814943	-	843	WP_049756048.1	host cell division inhibitor Icd-like protein	-
NJ8700_RS08445	1815183..1815485	-	303	WP_005702032.1	hypothetical protein	-
NJ8700_RS08450	1815765..1816262	-	498	WP_005702031.1	hypothetical protein	-
NJ8700_RS08455	1816334..1817099	-	766	Protein_1631	antA/AntB antirepressor family protein	-
NJ8700_RS08465	1817393..1817776	-	384	WP_005594660.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (13-110)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-80)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13326.24 Da
• Isoelectric Point: 9.7797

>T48571 WP_005702038.1 NZ_CP009230:c1813068-1812721 [Aggregatibacter aphrophilus NJ8700]
VKLLFIELPPFERYRKVHLSDDEYRAFQNELLENPEKGDVIQNTGGLRKIRIADSERNKGKRGGARVIYYYFLDGAQIWL
FSAYGKGEKADLNESEKRAFKVVLENLKAMARGKE

Nucleotide

• Length: 348 bp

>T48571 NZ_CP009230:c1813068-1812721 [Aggregatibacter aphrophilus NJ8700]
GTGAAACTATTATTTATTGAATTACCGCCCTTTGAGCGTTATAGAAAAGTGCATTTATCTGATGATGAATATCGGGCTTT
TCAAAATGAGTTATTAGAAAACCCCGAAAAAGGCGATGTGATACAAAATACAGGCGGATTGAGAAAAATTAGAATCGCTG
ACAGTGAGAGAAACAAAGGGAAACGTGGTGGCGCACGGGTGATTTATTACTACTTTTTAGACGGTGCGCAAATATGGCTT
TTTAGTGCTTACGGAAAAGGCGAAAAAGCAGACTTAAACGAAAGCGAGAAACGCGCATTTAAAGTGGTATTAGAGAATTT
AAAGGCAATGGCAAGGGGGAAAGAATGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11508.24 Da
• Isoelectric Point: 9.8103

>AT48571 WP_005702039.1 NZ_CP009230:c1812724-1812416 [Aggregatibacter aphrophilus NJ8700]
MSRLFDDLMEGAQALEQHLQGKITLRTETRERIEPASISAEEVKAIREKLNLSQAVFAQKLRTSVRTYQGWEQGKTKPSA
HASLLLRMVDKAPQTFELIAGI

Nucleotide

• Length: 309 bp

>AT48571 NZ_CP009230:c1812724-1812416 [Aggregatibacter aphrophilus NJ8700]
ATGAGCCGTTTATTTGATGATTTAATGGAAGGCGCGCAGGCTCTTGAGCAACATTTACAAGGTAAAATCACACTACGCAC
AGAAACGCGCGAACGAATTGAACCCGCAAGCATTAGTGCGGAGGAAGTGAAAGCAATTAGAGAGAAATTAAACCTTTCTC
AAGCTGTTTTTGCGCAGAAGTTACGAACCAGTGTAAGAACCTATCAAGGTTGGGAGCAAGGCAAAACCAAACCTAGCGCG
CACGCCTCTTTATTGTTGCGCATGGTGGACAAAGCACCGCAAACCTTCGAGCTTATCGCAGGGATATAA