Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1986151..1986661 Replicon chromosome
Accession NZ_CP009228
Organism Treponema putidum strain OMZ 758 (ATCC 700334)

Toxin (Protein)


Gene name yoeB Uniprot ID A0A562SEV4
Locus tag JO40_RS09035 Protein ID WP_044979050.1
Coordinates 1986401..1986661 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A562SEP5
Locus tag JO40_RS09030 Protein ID WP_044979049.1
Coordinates 1986151..1986408 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JO40_RS09010 1981413..1983284 - 1872 WP_044979046.1 RNB domain-containing ribonuclease -
JO40_RS09015 1983333..1985204 - 1872 WP_044979778.1 hypothetical protein -
JO40_RS09020 1985418..1985702 + 285 WP_044979047.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
JO40_RS09025 1985686..1986033 + 348 WP_144242350.1 type II toxin-antitoxin system RelE/ParE family toxin -
JO40_RS09030 1986151..1986408 + 258 WP_044979049.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JO40_RS09035 1986401..1986661 + 261 WP_044979050.1 Txe/YoeB family addiction module toxin Toxin
JO40_RS09040 1986730..1987203 + 474 WP_044979051.1 pantetheine-phosphate adenylyltransferase -
JO40_RS09050 1987626..1988014 - 389 Protein_1794 type II toxin-antitoxin system HicB family antitoxin -
JO40_RS09055 1988374..1990158 - 1785 WP_044979054.1 ABC transporter ATP-binding protein/permease -
JO40_RS12885 1990155..1990658 - 504 WP_144242270.1 DUF4135 domain-containing protein -
JO40_RS12890 1990601..1991203 - 603 WP_084224531.1 DUF4135 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10618.17 Da        Isoelectric Point: 9.9262

>T48568 WP_044979050.1 NZ_CP009228:1986401-1986661 [Treponema putidum]
MNKLFTDEAWADYIYWFNTDKKVLKRINDLIKEIERTPFTGKGKPEPLKYSLSGYWSRRINHEHRIVYQVEKQQLAFISF
RYHYEK

Download         Length: 261 bp

>T48568 NZ_CP009228:1986401-1986661 [Treponema putidum]
ATGAATAAACTCTTTACAGATGAGGCTTGGGCTGATTATATCTATTGGTTTAATACGGATAAAAAAGTTCTTAAAAGAAT
AAATGATTTGATAAAAGAAATCGAAAGAACGCCGTTTACGGGCAAGGGAAAACCGGAACCGTTAAAATATTCTTTGTCAG
GATATTGGTCAAGGCGGATAAATCATGAACATAGAATAGTATATCAAGTAGAAAAGCAGCAGTTAGCGTTTATTTCTTTT
AGGTACCACTATGAAAAATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10012.36 Da        Isoelectric Point: 6.2241

>AT48568 WP_044979049.1 NZ_CP009228:1986151-1986408 [Treponema putidum]
MDAITYSDLRRNLKAYMDKVYNDYEPLIISRKNSENVVLLSVREYNSLIETDYLLKNEANAAHLMKSIEQHRAGKIQKHE
LLQDE

Download         Length: 258 bp

>AT48568 NZ_CP009228:1986151-1986408 [Treponema putidum]
ATGGATGCAATTACATATTCGGATTTACGCCGCAATCTAAAAGCATATATGGACAAAGTTTACAATGACTATGAACCCTT
GATAATATCAAGGAAAAATTCGGAAAATGTGGTTCTTCTATCGGTACGTGAGTATAATAGTCTTATTGAAACCGATTATT
TGCTTAAGAACGAGGCGAATGCAGCTCATTTAATGAAATCAATTGAACAGCATAGAGCTGGGAAAATACAAAAACACGAG
TTGCTGCAAGATGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A562SEV4

Antitoxin

Source ID Structure
AlphaFold DB A0A562SEP5

References