Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1604071..1604605 Replicon plasmid pSymB
Accession NZ_CP009146
Organism Sinorhizobium meliloti strain RMO17

Toxin (Protein)


Gene name parE Uniprot ID Q92X99
Locus tag DU99_RS31720 Protein ID WP_010974986.1
Coordinates 1604071..1604367 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag DU99_RS31725 Protein ID WP_003527850.1
Coordinates 1604357..1604605 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU99_RS31695 1599513..1600916 - 1404 WP_026029937.1 sodium:alanine symporter family protein -
DU99_RS31700 1601450..1601659 - 210 WP_003527838.1 dodecin family protein -
DU99_RS31705 1601949..1602395 + 447 WP_014527651.1 DNA-binding protein -
DU99_RS31710 1602399..1602584 - 186 WP_010974989.1 hypothetical protein -
DU99_RS31715 1602751..1603149 - 399 WP_010974988.1 hypothetical protein -
DU99_RS34460 1603730..1603990 + 261 Protein_1459 helix-turn-helix domain containing protein -
DU99_RS31720 1604071..1604367 - 297 WP_010974986.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DU99_RS31725 1604357..1604605 - 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DU99_RS36330 1604713..1604868 - 156 WP_010974985.1 hypothetical protein -
DU99_RS34475 1605224..1605349 + 126 Protein_1463 IS481 family transposase -
DU99_RS31730 1605433..1606227 - 795 WP_013850206.1 methyltransferase domain-containing protein -
DU99_RS31735 1606231..1607031 - 801 WP_010974981.1 ABC transporter ATP-binding protein -
DU99_RS31740 1607028..1608071 - 1044 WP_010974980.1 iron ABC transporter permease -
DU99_RS31745 1608068..1609153 - 1086 WP_014530873.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1617037 1617037
- flank IS/Tn - - 1605158..1605349 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-91)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11473.15 Da        Isoelectric Point: 10.6593

>T48462 WP_010974986.1 NZ_CP009146:c1604367-1604071 [Sinorhizobium meliloti]
MATERPFRLAPTAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAVGTKKGRNVDVRPGYLKYPAGAHIVYFRDRGD
RIDIIRILHGRVDAQRHL

Download         Length: 297 bp

>T48462 NZ_CP009146:c1604367-1604071 [Sinorhizobium meliloti]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTACCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACACGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGACTGGCCGTAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGGCCGGGTTATCTCAAATACCCGGCAGGAGCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGTGTGGACGCCCAACGGCATTTGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT48462 WP_003527850.1 NZ_CP009146:c1604605-1604357 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT48462 NZ_CP009146:c1604605-1604357 [Sinorhizobium meliloti]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACAGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CCTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q92X99

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References