48459

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 307690..308245 Replicon plasmid pSymB
Accession NZ_CP009146
Organism Sinorhizobium meliloti strain RMO17

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DU99_RS25820 Protein ID WP_040120961.1
Coordinates 307928..308245 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID H0FXK0
Locus tag DU99_RS25815 Protein ID WP_003527850.1
Coordinates 307690..307938 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DU99_RS25795 303919..305250 + 1332 WP_040120960.1 O-antigen ligase family protein -
DU99_RS25800 305243..305998 + 756 WP_015242828.1 polysaccharide deacetylase family protein -
DU99_RS25805 306009..307238 + 1230 WP_015242829.1 glycosyltransferase family 4 protein -
DU99_RS25810 307355..307582 + 228 WP_015242830.1 hypothetical protein -
DU99_RS25815 307690..307938 + 249 WP_003527850.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
DU99_RS25820 307928..308245 + 318 WP_040120961.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DU99_RS33950 308216..308416 - 201 Protein_278 helix-turn-helix domain-containing protein -
DU99_RS25825 308738..309907 + 1170 WP_015242832.1 glycosyltransferase family 4 protein -
DU99_RS25830 309904..310293 + 390 WP_015242833.1 hypothetical protein -
DU99_RS25835 310324..311367 + 1044 WP_015242834.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Mobilizable plasmid - htpB 1..1617037 1617037


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-93)

Antitoxin

Antitoxin ParD

(3-78)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12311.12 Da        Isoelectric Point: 10.8610

>T48459 WP_040120961.1 NZ_CP009146:307928-308245 [Sinorhizobium meliloti]
MATERPFRLAPTAKADLRKIWRYTARRWSLEQAETYQDQLYTAFEGLAAGTKKGRNVDVRPGYLKYPAGAHIVYFRDRGD
RIDIIRILHGRMDAQRTHRAYMRAP

Download         Length: 318 bp

>T48459 NZ_CP009146:307928-308245 [Sinorhizobium meliloti]
ATGGCGACTGAACGGCCTTTCCGGCTCGCTCCTACCGCCAAGGCCGACCTTCGGAAGATATGGCGCTACACGGCTCGCCG
CTGGTCTCTGGAACAGGCGGAGACCTACCAAGACCAGCTTTATACTGCATTTGAGGGGCTGGCCGCAGGGACGAAGAAAG
GCCGCAATGTCGATGTGCGGCCGGGTTATCTCAAATACCCGGCAGGAGCGCACATCGTCTATTTTCGGGATCGCGGCGAC
CGGATCGACATCATCCGCATCCTGCATGGCCGGATGGACGCCCAACGAACGCATCGGGCTTATATGCGGGCGCCGTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8888.73 Da        Isoelectric Point: 4.2176

>AT48459 WP_003527850.1 NZ_CP009146:307690-307938 [Sinorhizobium meliloti]
MAARSTSISLGDHFAGFIDSQVQTGRYGSASDVVRAGLRLLEEHEAKVRALEAALIEGEESGEPEPFDNEAFKAEMRAEY
GD

Download         Length: 249 bp

>AT48459 NZ_CP009146:307690-307938 [Sinorhizobium meliloti]
ATGGCTGCTAGAAGCACATCTATTTCCCTTGGCGATCACTTCGCCGGTTTCATCGACAGCCAGGTGCAAACCGGCCGCTA
CGGCTCCGCCAGCGACGTTGTGCGGGCTGGACTTCGGCTTTTGGAAGAACACGAGGCGAAGGTAAGGGCGCTGGAAGCGG
CTTTGATCGAGGGCGAAGAATCCGGCGAGCCAGAGCCATTCGACAACGAAGCGTTCAAAGCCGAAATGCGCGCCGAATAT
GGCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H0FXK0

References