Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2690033..2690291 Replicon chromosome
Accession NZ_CP009072
Organism Escherichia coli ATCC 25922

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag DR76_RS13130 Protein ID WP_000809168.1
Coordinates 2690033..2690185 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 2690234..2690291 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR76_RS13110 2685278..2685991 - 714 WP_001102391.1 acidic protein MsyB -
DR76_RS13115 2686017..2686421 - 405 WP_000843687.1 DUF2541 family protein -
DR76_RS13120 2686793..2688709 + 1917 WP_000516135.1 molecular chaperone DnaK -
DR76_RS13125 2688798..2689928 + 1131 WP_001118465.1 molecular chaperone DnaJ -
DR76_RS13130 2690033..2690185 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 2690234..2690291 + 58 - - Antitoxin
DR76_RS13135 2690800..2691561 + 762 WP_001274832.1 hypothetical protein -
DR76_RS13140 2691581..2693074 + 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
DR76_RS13145 2693203..2694462 + 1260 WP_000494928.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T48214 WP_000809168.1 NZ_CP009072:c2690185-2690033 [Escherichia coli ATCC 25922]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T48214 NZ_CP009072:c2690185-2690033 [Escherichia coli ATCC 25922]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT48214 NZ_CP009072:2690234-2690291 [Escherichia coli ATCC 25922]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References