Detailed information of TA system TA047965

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 3786062..3786756
• Replicon: chromosome
• Accession: NZ_CP008943
• Organism: Yersinia pseudotuberculosis strain ATCC 6904

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: DJ40_RS16995
• Protein ID: WP_024063131.1
• Coordinates: 3786062..3786358 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q666X1
• Locus tag: DJ40_RS17000
• Protein ID: WP_002209924.1
• Coordinates: 3786358..3786756 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DJ40_RS16960	3781184..3782701	+	1518	WP_002209930.1	lysine--tRNA ligase	-
DJ40_RS16970	3783134..3784348	+	1215	WP_011192954.1	tyrosine-type recombinase/integrase	-
DJ40_RS16975	3784430..3784615	-	186	WP_002209928.1	hypothetical protein	-
DJ40_RS16985	3785213..3785473	+	261	WP_002214785.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DJ40_RS16990	3785536..3785898	+	363	WP_011192920.1	helix-turn-helix domain-containing protein	-
DJ40_RS16995	3786062..3786358	+	297	WP_024063131.1	type II toxin-antitoxin system MqsR family toxin	Toxin
DJ40_RS17000	3786358..3786756	+	399	WP_002209924.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
DJ40_RS17005	3787156..3789447	-	2292	WP_038401050.1	toprim domain-containing protein	-
DJ40_RS17010	3789747..3790073	+	327	WP_002209922.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DJ40_RS24140	3790066..3790218	+	153	WP_002209921.1	hypothetical protein	-
DJ40_RS17020	3790232..3790432	-	201	WP_002209920.1	AlpA family transcriptional regulator	-
DJ40_RS23995	3790614..3790946	-	333	WP_032466587.1	hypothetical protein	-
DJ40_RS24000	3791061..3791294	-	234	Protein_3253	hypothetical protein	-
DJ40_RS17035	3791307..3791672	-	366	WP_002209919.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11318.17 Da
• Isoelectric Point: 7.8810

>T47965 WP_024063131.1 NZ_CP008943:3786062-3786358 [Yersinia pseudotuberculosis]
MEKRTPHTRLLKVKELVLKGNIKTTRTARDGAEELGLSFRDMCDAVSELISADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEI

Nucleotide

• Length: 297 bp

>T47965 NZ_CP008943:3786062-3786358 [Yersinia pseudotuberculosis]
ATGGAGAAACGGACTCCGCATACTCGTTTATTAAAAGTAAAAGAATTGGTATTGAAGGGGAATATTAAAACGACACGAAC
TGCCAGAGATGGGGCTGAGGAACTGGGACTGAGTTTTAGAGATATGTGTGATGCAGTTTCCGAACTGATTAGCGCCGATT
TTTATAAAAGTATGACGACACATCAAGATCATACCATTTGGCAGGATGTTTACCGTCCTATGCTTTCTTGCGGTAGAGTT
TATTTGAAAATCACGGTTATCGATGATGTTTTGATTGTCTCGTTTAAGGAGATTTAA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 14657.17 Da
• Isoelectric Point: 8.4923

>AT47965 WP_002209924.1 NZ_CP008943:3786358-3786756 [Yersinia pseudotuberculosis]
MMKCPVCGGVELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETVMTEAESDVYAAKTMLLRKMVNTESIAPAYIVQIRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHPSTIKLLQVLDKHPELLNEIR

Nucleotide

• Length: 399 bp

>AT47965 NZ_CP008943:3786358-3786756 [Yersinia pseudotuberculosis]
ATGATGAAATGTCCAGTTTGTGGCGGTGTAGAATTAATCCACGAAGCGCGTGACGTTCCCTTTACCTATAAAGGGCGTAA
GTTCATCGTCGAAGGCGTGATAGGGCAACATTGCCCGGCATGCGGTGAAACAGTCATGACCGAAGCCGAGTCCGATGTCT
ATGCAGCAAAAACAATGCTTTTGCGAAAAATGGTCAATACAGAATCGATTGCCCCCGCATATATTGTGCAGATCCGAAAA
AAGTTGGGCCTAAACCAGCGGGAAGCCAGTGAGATTTTTGGTGGTGGGGTTAATGCATTTTCGCGTTACGAAAAAGGTAA
GGCTTTGCCACATCCATCAACGATAAAACTGTTGCAAGTGCTTGATAAACACCCGGAGTTATTGAATGAAATTAGGTAG

Structures

Antitoxin

• AlphaFold DB: Q666X1