Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 2083206..2083725 Replicon chromosome
Accession NZ_CP008921
Organism Streptococcus suis 6407

Toxin (Protein)


Gene name yoeB Uniprot ID A0A075SJE9
Locus tag ID09_RS10235 Protein ID WP_024381174.1
Coordinates 2083206..2083463 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A075STV3
Locus tag ID09_RS10240 Protein ID WP_029693774.1
Coordinates 2083465..2083725 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ID09_RS10220 2079678..2081408 - 1731 WP_024381172.1 membrane protein -
ID09_RS10225 2081770..2082678 - 909 WP_074390583.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
ID09_RS10230 2082662..2083192 - 531 WP_024381173.1 DUF1697 domain-containing protein -
ID09_RS10235 2083206..2083463 - 258 WP_024381174.1 Txe/YoeB family addiction module toxin Toxin
ID09_RS10240 2083465..2083725 - 261 WP_029693774.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ID09_RS10245 2083801..2084256 - 456 WP_024381175.1 8-oxo-dGTP diphosphatase -
ID09_RS10250 2084263..2084592 - 330 WP_024381176.1 type II toxin-antitoxin system RelE/ParE family toxin -
ID09_RS10255 2084582..2084869 - 288 WP_024381177.1 hypothetical protein -
ID09_RS10260 2084967..2085335 - 369 WP_024381178.1 hypothetical protein -
ID09_RS10265 2085328..2085894 - 567 WP_024381179.1 ribonuclease M5 -
ID09_RS10270 2085878..2086660 - 783 WP_024381180.1 TatD family hydrolase -
ID09_RS10275 2086767..2086904 - 138 WP_002939016.1 50S ribosomal protein L34 -
ID09_RS10280 2087072..2088067 - 996 WP_024381181.1 protein jag -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10392.94 Da        Isoelectric Point: 8.0279

>T47924 WP_024381174.1 NZ_CP008921:c2083463-2083206 [Streptococcus suis 6407]
MGIHFTEDAWEDYLYWQGQDKKTLKRINKIIKDMQRHPFEGIAKPEPLKYDYQGAWSRRIDAENRLIYMMEADRLCILSL
KDHYR

Download         Length: 258 bp

>T47924 NZ_CP008921:c2083463-2083206 [Streptococcus suis 6407]
ATGGGAATCCATTTTACAGAGGATGCCTGGGAAGACTATCTTTATTGGCAGGGTCAGGATAAGAAAACACTGAAGAGAAT
CAATAAGATTATCAAGGATATGCAACGACACCCGTTTGAAGGTATTGCCAAGCCAGAACCCTTGAAGTATGATTATCAAG
GTGCCTGGTCGAGACGGATTGATGCGGAGAATCGGTTGATTTATATGATGGAAGCTGATCGGTTGTGCATCCTGTCGCTA
AAGGATCATTATAGGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9920.27 Da        Isoelectric Point: 5.1255

>AT47924 WP_029693774.1 NZ_CP008921:c2083725-2083465 [Streptococcus suis 6407]
MEAIVYSHFRNHLKDYMKKVNDEFEPLVVVNKNPEEDIVVLSKSEWDSLQETLAVARNAYLSQKVLRGMAQVKAGQTQER
NLIEAD

Download         Length: 261 bp

>AT47924 NZ_CP008921:c2083725-2083465 [Streptococcus suis 6407]
ATGGAAGCTATTGTATATTCCCATTTTCGAAACCACTTAAAGGACTATATGAAAAAGGTCAATGACGAGTTTGAGCCTTT
GGTCGTGGTTAATAAAAATCCAGAGGAAGATATTGTTGTACTCTCAAAGAGTGAGTGGGATAGTTTACAAGAAACCCTTG
CTGTTGCTCGGAACGCCTACCTATCTCAGAAAGTCTTGCGTGGTATGGCTCAAGTCAAAGCGGGACAAACCCAAGAACGA
AACCTGATAGAGGCGGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A075SJE9

Antitoxin

Source ID Structure
AlphaFold DB A0A075STV3

References