Detailed information of TA system TA047910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/Tad-HTH_37
• Location: 1094328..1094985
• Replicon: chromosome
• Accession: NZ_CP008911
• Organism: Burkholderia pseudomallei HBPUB10134a

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: DR55_RS04780
• Protein ID: WP_009972517.1
• Coordinates: 1094653..1094985 (-)
• Length: 111 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DR55_RS31705
• Protein ID: WP_009972518.1
• Coordinates: 1094328..1094645 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DR55_RS04765	1090312..1091181	-	870	WP_004189208.1	patatin-like phospholipase family protein	-
DR55_RS04770	1091219..1091623	-	405	WP_004200732.1	PaaI family thioesterase	-
DR55_RS38380	1092238..1092900	-	663	WP_133670743.1	hypothetical protein	-
DR55_RS31700	1092921..1094129	-	1209	WP_009972519.1	DUF262 domain-containing protein	-
DR55_RS31705	1094328..1094645	-	318	WP_009972518.1	helix-turn-helix domain-containing protein	Antitoxin
DR55_RS04780	1094653..1094985	-	333	WP_009972517.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DR55_RS04795	1096558..1097040	+	483	WP_004200731.1	DUF2778 domain-containing protein	-
DR55_RS04800	1097037..1097321	+	285	WP_004523107.1	hypothetical protein	-
DR55_RS04805	1097395..1098486	-	1092	WP_038724261.1	phage portal protein	-
DR55_RS04810	1099137..1099571	+	435	WP_009969936.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (19-104)

Antitoxin

• Cro/C1-type helix-turn-helix domain (47-100)

Sequences

Toxin

Protein

• Length: 111 a.a.
• Molecular weight: 12820.92 Da
• Isoelectric Point: 10.3618

>T47910 WP_009972517.1 NZ_CP008911:c1094985-1094653 [Burkholderia pseudomallei HBPUB10134a]
MKLDWTVIYYNERVKRDVFAFPAGILADYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPKGREGIGRVFYCTHVGQQVV
VLHSFVKKTQETPQRELRIAQARLREVRNG

Nucleotide

• Length: 333 bp

>T47910 NZ_CP008911:c1094985-1094653 [Burkholderia pseudomallei HBPUB10134a]
ATGAAACTTGATTGGACGGTCATCTACTACAACGAACGGGTGAAGCGCGACGTTTTCGCGTTCCCGGCCGGGATTCTTGC
AGACTACCTCCGGCTGTTGGATCTGATGCAAGAGTTCGGTGCGGATCTACGGATGCCGCATTCACGAGCAATGGGTAACG
GGCTGTTTGAACTGCGCCCCAAGGGTAGGGAAGGTATCGGGCGGGTGTTCTATTGCACGCATGTGGGGCAGCAAGTCGTT
GTGCTGCACTCCTTTGTCAAGAAGACGCAGGAAACGCCGCAACGTGAGTTGCGGATCGCCCAAGCACGTTTGAGGGAGGT
GCGTAATGGCTAA

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11321.89 Da
• Isoelectric Point: 10.2231

>AT47910 WP_009972518.1 NZ_CP008911:c1094645-1094328 [Burkholderia pseudomallei HBPUB10134a]
VKRVRAEGFNPVPHTADDTVRLLAGRNVKTAYDALEDEYTALRAILSARREAGLTQAQIAERMGTTASAVSRLEASLSSE
KHSPSFATLRKYAAACGKKLVISFA

Nucleotide

• Length: 318 bp

>AT47910 NZ_CP008911:c1094645-1094328 [Burkholderia pseudomallei HBPUB10134a]
GTGAAGCGTGTTCGCGCTGAGGGATTCAATCCAGTTCCGCACACAGCGGACGACACGGTGCGTCTGCTCGCCGGTCGCAA
TGTCAAGACGGCGTATGACGCGCTGGAAGACGAATATACGGCGCTGCGCGCGATTCTGTCTGCTCGTCGGGAAGCGGGTC
TGACGCAGGCGCAAATAGCCGAACGTATGGGCACAACCGCGTCAGCGGTTTCAAGGCTTGAGGCATCTTTGTCGAGTGAA
AAGCATTCGCCGTCGTTCGCGACTCTCCGTAAATATGCGGCCGCGTGCGGCAAAAAGCTCGTAATTTCATTTGCTTAG