Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 141220..141866 Replicon chromosome
Accession NZ_CP008897
Organism Enterobacter hormaechei subsp. hoffmannii ECNIH3

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag ECNIH3_RS00680 Protein ID WP_038415013.1
Coordinates 141516..141866 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag ECNIH3_RS00675 Protein ID WP_038415012.1
Coordinates 141220..141519 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECNIH3_RS00650 136688..137272 - 585 WP_038415008.1 type 1 fimbrial protein -
ECNIH3_RS00655 137325..137927 - 603 WP_038415009.1 response regulator transcription factor -
ECNIH3_RS00660 138762..139550 + 789 WP_038415010.1 winged helix-turn-helix domain-containing protein -
ECNIH3_RS00665 139552..140031 + 480 WP_022646606.1 hypothetical protein -
ECNIH3_RS00670 140274..141155 + 882 WP_038415011.1 helix-turn-helix domain-containing protein -
ECNIH3_RS00675 141220..141519 - 300 WP_038415012.1 XRE family transcriptional regulator Antitoxin
ECNIH3_RS00680 141516..141866 - 351 WP_038415013.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
ECNIH3_RS25475 142134..142386 - 253 Protein_138 DNA-binding protein -
ECNIH3_RS00690 142489..142830 - 342 WP_038415015.1 SymE family type I addiction module toxin -
ECNIH3_RS00695 142956..143147 + 192 WP_038416963.1 toxin-antitoxin system HicB family antitoxin -
ECNIH3_RS00700 143153..143779 - 627 WP_051979808.1 hypothetical protein -
ECNIH3_RS00710 144243..145634 + 1392 WP_023299010.1 glycoside-pentoside-hexuronide family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13521.57 Da        Isoelectric Point: 8.8448

>T47870 WP_038415013.1 NZ_CP008897:c141866-141516 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
MWTVLFSKVFEQWLLEQEDGLQEKVLADLLNLQNYGPRLPRPYADTVKGSQYKNMKELRIQYAGRPVRAFFAFDPVRQAI
VLCAGDKRNDKTFYEKLIRIADAEFTHHLTSLEAAK

Download         Length: 351 bp

>T47870 NZ_CP008897:c141866-141516 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
ATGTGGACGGTACTGTTTAGTAAGGTATTCGAGCAATGGTTGCTTGAACAGGAAGATGGGTTGCAGGAAAAGGTACTGGC
AGACCTGTTAAATCTACAGAATTATGGACCGCGTCTTCCTCGTCCCTATGCGGATACCGTTAAGGGCTCACAGTATAAGA
ATATGAAAGAGTTACGTATTCAATATGCGGGTCGCCCGGTTCGTGCGTTCTTCGCGTTTGATCCTGTACGTCAGGCCATT
GTGCTTTGCGCGGGCGATAAGCGTAATGACAAAACCTTTTATGAAAAACTGATTCGCATTGCAGATGCCGAATTCACCCA
TCATCTGACAAGCCTGGAGGCAGCCAAGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11057.80 Da        Isoelectric Point: 6.4695

>AT47870 WP_038415012.1 NZ_CP008897:c141519-141220 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
VKTLNEVIASRSPESQQRIQEMAEEMFLETGLQLLREELQLSQKHVAALMGVSQPAVTQLEQRGNDLKIATLKRYIEAMG
GKLSINVELPTGKQVAFHL

Download         Length: 300 bp

>AT47870 NZ_CP008897:c141519-141220 [Enterobacter hormaechei subsp. hoffmannii ECNIH3]
GTGAAAACCTTAAATGAAGTGATTGCGTCACGCTCACCGGAAAGCCAACAGCGCATTCAGGAGATGGCAGAGGAAATGTT
CCTCGAAACCGGTCTGCAACTTCTGCGTGAAGAGCTCCAGCTTTCGCAAAAACATGTCGCCGCTCTTATGGGCGTAAGTC
AACCTGCGGTAACACAGCTGGAGCAGCGTGGAAACGATCTGAAGATTGCTACGCTTAAGCGTTACATCGAAGCGATGGGC
GGAAAACTTAGCATTAACGTGGAACTACCCACTGGCAAGCAGGTTGCGTTTCATCTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References