47845

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1182860..1183426 Replicon chromosome
Accession NZ_CP008885
Organism Bifidobacterium longum strain BXY01

Toxin (Protein)


Gene name relE Uniprot ID W6EX94
Locus tag GS08_RS05015 Protein ID WP_003831807.1
Coordinates 1182860..1183153 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7U4H5P9
Locus tag GS08_RS05020 Protein ID WP_038425943.1
Coordinates 1183157..1183426 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GS08_RS04985 1178296..1178952 + 657 WP_013140724.1 ATP-binding cassette domain-containing protein -
GS08_RS04990 1178955..1179683 + 729 WP_013140725.1 hypothetical protein -
GS08_RS04995 1179680..1180303 + 624 WP_016462919.1 hypothetical protein -
GS08_RS05000 1180507..1181382 + 876 WP_013140727.1 EamA family transporter -
GS08_RS05005 1181506..1181868 + 363 WP_013140728.1 hypothetical protein -
GS08_RS05015 1182860..1183153 - 294 WP_003831807.1 type II toxin-antitoxin system YafQ family toxin Toxin
GS08_RS05020 1183157..1183426 - 270 WP_038425943.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
GS08_RS05025 1183611..1184780 - 1170 WP_013140730.1 ABC transporter permease -
GS08_RS05030 1184777..1185457 - 681 WP_013140731.1 ABC transporter ATP-binding protein -
GS08_RS05035 1185454..1186344 - 891 WP_013140732.1 hypothetical protein -
GS08_RS05040 1186341..1186856 - 516 WP_013140733.1 hypothetical protein -
GS08_RS05045 1186982..1187677 + 696 WP_003829410.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 1153427..1196819 43392


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(3-87)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11218.98 Da        Isoelectric Point: 9.7881

>T47845 WP_003831807.1 NZ_CP008885:c1183153-1182860 [Bifidobacterium longum]
MLKPDYTAAFQRDIKKLKRKHTDLRPLKEVIRLVLEDTADSKEVLRRRHRAHTLTGDLNGVLECHIGNAGDWLLLWIRDD
GTAMFMRTGSHDELLGK

Download         Length: 294 bp

>T47845 NZ_CP008885:c1183153-1182860 [Bifidobacterium longum]
ATGCTCAAACCGGATTACACAGCGGCATTCCAGCGAGATATCAAGAAACTCAAACGCAAGCACACTGATTTACGCCCGCT
GAAAGAAGTCATTCGTCTGGTTCTTGAGGACACGGCGGACTCCAAGGAAGTATTGAGGCGTAGGCATCGCGCCCACACAC
TTACCGGTGATTTAAACGGCGTACTGGAATGCCACATCGGCAATGCCGGCGACTGGCTGCTTCTATGGATTCGCGATGAT
GGTACCGCCATGTTCATGCGAACCGGCAGCCATGACGAACTGTTGGGCAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9830.14 Da        Isoelectric Point: 5.0790

>AT47845 WP_038425943.1 NZ_CP008885:c1183426-1183157 [Bifidobacterium longum]
VSMASVTVRVDADTKQKAANIAEDLGLDLSSVTRAFYKQIVRERRIPLNLSYTTVPPATMEALDEAKNRLADGRPRFNSA
DEMFDSLGI

Download         Length: 270 bp

>AT47845 NZ_CP008885:c1183426-1183157 [Bifidobacterium longum]
GTGAGCATGGCATCCGTCACAGTCCGCGTGGATGCGGACACCAAGCAGAAAGCCGCAAACATAGCCGAGGATCTCGGTCT
GGACTTGTCTTCGGTCACCCGCGCCTTCTACAAGCAGATTGTCCGGGAGAGGCGCATTCCCCTAAACCTTTCCTATACGA
CCGTGCCGCCTGCAACCATGGAGGCCCTTGACGAGGCGAAGAACAGGCTCGCCGACGGCCGACCTCGCTTCAACAGTGCC
GATGAGATGTTCGATTCGTTGGGAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W6EX94

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4H5P9

References