47796

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 1463142..1463737 Replicon chromosome
Accession NZ_CP008867
Organism Pseudomonas aeruginosa strain T52373

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HW00_RS29020 Protein ID WP_071535843.1
Coordinates 1463459..1463737 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HW00_RS06805 Protein ID WP_003099268.1
Coordinates 1463142..1463447 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW00_RS06795 1458913..1459203 - 291 WP_058007095.1 DUF5447 family protein -
HW00_RS06800 1459415..1459687 - 273 WP_059317094.1 hypothetical protein -
HW00_RS28995 1459797..1460063 + 267 WP_016253917.1 hypothetical protein -
HW00_RS29000 1460119..1460454 + 336 WP_079758266.1 hypothetical protein -
HW00_RS29005 1460485..1461630 - 1146 WP_079758298.1 DNA adenine methylase -
HW00_RS29010 1461754..1462047 + 294 WP_079758267.1 helix-turn-helix domain-containing protein -
HW00_RS29015 1462040..1462828 + 789 WP_079758268.1 restriction endonuclease -
HW00_RS06805 1463142..1463447 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
HW00_RS29020 1463459..1463737 - 279 WP_071535843.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW00_RS06810 1464066..1466294 + 2229 WP_021264080.1 TonB-dependent receptor -
HW00_RS06815 1466365..1467012 - 648 WP_003095021.1 carbonate dehydratase -
HW00_RS06820 1467074..1468312 - 1239 WP_034013624.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10674.25 Da        Isoelectric Point: 7.8937

>T47796 WP_071535843.1 NZ_CP008867:c1463737-1463459 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T47796 NZ_CP008867:c1463737-1463459 [Pseudomonas aeruginosa]
CTGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGTGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT47796 WP_003099268.1 NZ_CP008867:c1463447-1463142 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT47796 NZ_CP008867:c1463447-1463142 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References