Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | higBA (relBE)/HigB-VapI |
Location | 5863436..5864031 | Replicon | chromosome |
Accession | NZ_CP008864 | ||
Organism | Pseudomonas aeruginosa strain W60856 |
Toxin (Protein)
Gene name | higB | Uniprot ID | - |
Locus tag | HV95_RS27975 | Protein ID | WP_071536079.1 |
Coordinates | 5863753..5864031 (-) | Length | 93 a.a. |
Antitoxin (Protein)
Gene name | higA | Uniprot ID | - |
Locus tag | HV95_RS27970 | Protein ID | WP_003099268.1 |
Coordinates | 5863436..5863741 (-) | Length | 102 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HV95_RS27940 | 5859415..5859993 | - | 579 | Protein_5408 | DNA cytosine methyltransferase | - |
HV95_RS27945 | 5860001..5860288 | - | 288 | WP_031689773.1 | DUF5447 family protein | - |
HV95_RS27950 | 5860464..5860736 | - | 273 | WP_004352675.1 | hypothetical protein | - |
HV95_RS27955 | 5860846..5861112 | + | 267 | WP_023088595.1 | hypothetical protein | - |
HV95_RS27960 | 5861168..5861503 | + | 336 | WP_031689774.1 | hypothetical protein | - |
HV95_RS32990 | 5861556..5862647 | + | 1092 | WP_124132249.1 | hypothetical protein | - |
HV95_RS27965 | 5862863..5863099 | - | 237 | WP_059309835.1 | hypothetical protein | - |
HV95_RS27970 | 5863436..5863741 | - | 306 | WP_003099268.1 | HigA family addiction module antidote protein | Antitoxin |
HV95_RS27975 | 5863753..5864031 | - | 279 | WP_071536079.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
HV95_RS27985 | 5864360..5866588 | + | 2229 | WP_031689776.1 | TonB-dependent receptor | - |
HV95_RS27990 | 5866658..5867305 | - | 648 | WP_003095021.1 | carbonate dehydratase | - |
HV95_RS27995 | 5867367..5868605 | - | 1239 | WP_017001387.1 | C69 family dipeptidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10632.17 Da Isoelectric Point: 7.8937
>T47775 WP_071536079.1 NZ_CP008864:c5864031-5863753 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAGTELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAGTELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH
Download Length: 279 bp
>T47775 NZ_CP008864:c5864031-5863753 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGGTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGGTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA
Antitoxin
Download Length: 102 a.a. Molecular weight: 11213.79 Da Isoelectric Point: 5.0747
>AT47775 WP_003099268.1 NZ_CP008864:c5863741-5863436 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG
Download Length: 306 bp
>AT47775 NZ_CP008864:c5863741-5863436 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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