Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5863436..5864031 Replicon chromosome
Accession NZ_CP008864
Organism Pseudomonas aeruginosa strain W60856

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HV95_RS27975 Protein ID WP_071536079.1
Coordinates 5863753..5864031 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HV95_RS27970 Protein ID WP_003099268.1
Coordinates 5863436..5863741 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HV95_RS27940 5859415..5859993 - 579 Protein_5408 DNA cytosine methyltransferase -
HV95_RS27945 5860001..5860288 - 288 WP_031689773.1 DUF5447 family protein -
HV95_RS27950 5860464..5860736 - 273 WP_004352675.1 hypothetical protein -
HV95_RS27955 5860846..5861112 + 267 WP_023088595.1 hypothetical protein -
HV95_RS27960 5861168..5861503 + 336 WP_031689774.1 hypothetical protein -
HV95_RS32990 5861556..5862647 + 1092 WP_124132249.1 hypothetical protein -
HV95_RS27965 5862863..5863099 - 237 WP_059309835.1 hypothetical protein -
HV95_RS27970 5863436..5863741 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
HV95_RS27975 5863753..5864031 - 279 WP_071536079.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HV95_RS27985 5864360..5866588 + 2229 WP_031689776.1 TonB-dependent receptor -
HV95_RS27990 5866658..5867305 - 648 WP_003095021.1 carbonate dehydratase -
HV95_RS27995 5867367..5868605 - 1239 WP_017001387.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10632.17 Da        Isoelectric Point: 7.8937

>T47775 WP_071536079.1 NZ_CP008864:c5864031-5863753 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAGTELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T47775 NZ_CP008864:c5864031-5863753 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGGTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT47775 WP_003099268.1 NZ_CP008864:c5863741-5863436 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT47775 NZ_CP008864:c5863741-5863436 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References