Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5436603..5437198 Replicon chromosome
Accession NZ_CP008862
Organism Pseudomonas aeruginosa strain M1608

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag HW04_RS25970 Protein ID WP_003113526.1
Coordinates 5436920..5437198 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HW04_RS25965 Protein ID WP_003133769.1
Coordinates 5436603..5436908 (-) Length 102 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW04_RS30925 5432303..5432884 + 582 WP_123903235.1 sce7726 family protein -
HW04_RS25950 5432871..5433941 - 1071 WP_023098928.1 beta family protein -
HW04_RS25955 5433931..5434767 - 837 WP_023098927.1 ImmA/IrrE family metallo-endopeptidase -
HW04_RS30930 5434760..5435434 - 675 WP_023098926.1 N-acetyltransferase -
HW04_RS25960 5435860..5436267 - 408 WP_049267485.1 hypothetical protein -
HW04_RS25965 5436603..5436908 - 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
HW04_RS25970 5436920..5437198 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW04_RS25980 5437527..5439755 + 2229 WP_003141628.1 TonB-dependent receptor -
HW04_RS25985 5439825..5440472 - 648 WP_003095021.1 carbonate dehydratase -
HW04_RS25990 5440534..5441772 - 1239 WP_003141631.1 C69 family dipeptidase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-92)

Antitoxin

(6-82)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T47762 WP_003113526.1 NZ_CP008862:c5437198-5436920 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T47762 NZ_CP008862:c5437198-5436920 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT47762 WP_003133769.1 NZ_CP008862:c5436908-5436603 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT47762 NZ_CP008862:c5436908-5436603 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V6ALY3


Antitoxin

Source ID Structure

References