Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5493086..5493681 Replicon chromosome
Accession NZ_CP008856
Organism Pseudomonas aeruginosa strain F23197

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HW10_RS25820 Protein ID WP_079384851.1
Coordinates 5493403..5493681 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HW10_RS25815 Protein ID WP_003099268.1
Coordinates 5493086..5493391 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HW10_RS25780 5488237..5489085 + 849 WP_003146058.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
HW10_RS25790 5489252..5490193 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
HW10_RS25795 5490310..5490924 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
HW10_RS25800 5490966..5491550 + 585 WP_033937311.1 aminoacyl-tRNA hydrolase -
HW10_RS25805 5491591..5492691 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
HW10_RS25815 5493086..5493391 - 306 WP_003099268.1 HigA family addiction module antidote protein Antitoxin
HW10_RS25820 5493403..5493681 - 279 WP_079384851.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HW10_RS25830 5494010..5496238 + 2229 WP_033937312.1 TonB-dependent receptor -
HW10_RS25835 5496308..5496955 - 648 WP_003095021.1 carbonate dehydratase -
HW10_RS25840 5497017..5498255 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10676.22 Da        Isoelectric Point: 7.8937

>T47720 WP_079384851.1 NZ_CP008856:c5493681-5493403 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLTMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T47720 NZ_CP008856:c5493681-5493403 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCACAATGCTTCATGCGGCTACGGAGCTTCGAGACCTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT47720 WP_003099268.1 NZ_CP008856:c5493391-5493086 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp

>AT47720 NZ_CP008856:c5493391-5493086 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTATTCGTTAGCA
ACTGCTTATGCGGCGAATGGCAAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References