Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 129101..129831 | Replicon | chromosome |
| Accession | NZ_CP008823 | ||
| Organism | UNVERIFIED_ORG: Enterobacter cloacae ECNIH2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A837FIL2 |
| Locus tag | ECNIH2_RS00620 | Protein ID | WP_023302825.1 |
| Coordinates | 129101..129415 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | ECNIH2_RS00625 | Protein ID | WP_023302826.1 |
| Coordinates | 129412..129831 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ECNIH2_RS00595 (ECNIH2_00600) | 124120..125319 | - | 1200 | WP_014603550.1 | site-specific integrase | - |
| ECNIH2_RS29100 | 125493..125852 | + | 360 | Protein_123 | hypothetical protein | - |
| ECNIH2_RS00600 (ECNIH2_00605) | 125758..126942 | - | 1185 | WP_015570118.1 | multidrug efflux MFS transporter EmrD | - |
| ECNIH2_RS00605 (ECNIH2_00610) | 127118..127951 | - | 834 | WP_032620535.1 | DMT family transporter | - |
| ECNIH2_RS00610 (ECNIH2_00615) | 128014..128460 | - | 447 | WP_003861064.1 | GNAT family N-acetyltransferase | - |
| ECNIH2_RS00620 (ECNIH2_00625) | 129101..129415 | + | 315 | WP_023302825.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| ECNIH2_RS00625 (ECNIH2_00630) | 129412..129831 | + | 420 | WP_023302826.1 | helix-turn-helix domain-containing protein | Antitoxin |
| ECNIH2_RS28365 | 129978..130076 | + | 99 | WP_057979964.1 | ilvB operon leader peptide IvbL | - |
| ECNIH2_RS00630 (ECNIH2_00635) | 130183..131871 | + | 1689 | WP_023302827.1 | acetolactate synthase large subunit | - |
| ECNIH2_RS00635 (ECNIH2_00640) | 131875..132162 | + | 288 | WP_015570113.1 | acetolactate synthase small subunit | - |
| ECNIH2_RS00640 (ECNIH2_00645) | 132288..132881 | + | 594 | WP_003861054.1 | transcriptional regulator UhpA | - |
| ECNIH2_RS00645 (ECNIH2_00650) | 132878..134383 | + | 1506 | WP_017694010.1 | signal transduction histidine-protein kinase/phosphatase UhpB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 85625..136658 | 51033 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12415.51 Da Isoelectric Point: 10.2825
>T47624 WP_023302825.1 NZ_CP008823:129101-129415 [Enterobacter cloacae ECNIH2]
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK
MHLISMKAILDAVSQFPQHREELLFLGRVIEKSHCPTPAALRKLFPTLDNFKYLDKHYVIDIANNNLRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK
Download Length: 315 bp
>T47624 NZ_CP008823:129101-129415 [Enterobacter cloacae ECNIH2]
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA
ATGCATTTAATCTCAATGAAGGCAATTTTGGATGCGGTAAGCCAGTTCCCGCAACACAGAGAAGAGCTTCTCTTTTTAGG
ACGAGTTATTGAAAAGAGCCACTGCCCGACGCCCGCTGCACTGAGAAAACTTTTCCCAACGCTGGATAACTTCAAGTATC
TTGATAAGCATTATGTTATTGATATTGCAAATAACAATCTCAGAGTAGTGGCTCTCATATTCTTTGAAAGCCAAAAGTTT
TATGTGCGCCATGTTTTTACTCATAAGGAATATGACCGTTTTACGGAGAAACATCGCACTAAGGGGAAGAAATGA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15380.96 Da Isoelectric Point: 5.2068
>AT47624 WP_023302826.1 NZ_CP008823:129412-129831 [Enterobacter cloacae ECNIH2]
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANGPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE
MMIVADAMKATHALVAAVPLLGEQPSEKDYKDALELVEYLLMNEPNSPLLDIVCARISHYEANGPEIVALRKEMESVPVG
IAVLRTLMDQYNLTISDFKDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE
Download Length: 420 bp
>AT47624 NZ_CP008823:129412-129831 [Enterobacter cloacae ECNIH2]
ATGATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGA
GAAAGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGTCCTTTGCTGGATATTGTGT
GCGCCAGAATTAGCCATTACGAAGCTAATGGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTCGGA
ATTGCAGTTTTAAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGAT
GGTTTCACGGGTTCTGAATGGTCAGAGACAGCTTACCCTGAACCATATTAAAAAGCTGGCGGCCAGATTTGGGGTATCAC
CTGCGTTATTTATTGAGTGA
ATGATGATCGTCGCTGATGCAATGAAAGCTACGCACGCCCTTGTTGCGGCCGTTCCTTTACTGGGTGAACAGCCGAGCGA
GAAAGATTATAAGGATGCGCTTGAGCTGGTTGAGTATCTCCTTATGAACGAGCCCAATAGTCCTTTGCTGGATATTGTGT
GCGCCAGAATTAGCCATTACGAAGCTAATGGGCCAGAGATAGTCGCATTACGCAAGGAGATGGAGTCCGTTCCCGTCGGA
ATTGCAGTTTTAAGAACCTTGATGGATCAATACAATCTGACGATATCGGATTTTAAGGATGAAATTGGTAGTAAATCGAT
GGTTTCACGGGTTCTGAATGGTCAGAGACAGCTTACCCTGAACCATATTAAAAAGCTGGCGGCCAGATTTGGGGTATCAC
CTGCGTTATTTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|