Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-RNAII/-
Location 1919603..1920066 Replicon chromosome
Accession NZ_CP008816
Organism Enterococcus faecalis ATCC 29212

Toxin (Protein)


Gene name txpA Uniprot ID S4BYM2
Locus tag DR75_RS15720 Protein ID WP_002392696.1
Coordinates 1919603..1919746 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name RNAII
Locus tag -
Coordinates 1919922..1920066 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DR75_RS10155 (DR75_1874) 1914944..1917688 + 2745 WP_002404005.1 glycoside hydrolase family 65 protein -
DR75_RS10160 (DR75_1875) 1917703..1918353 + 651 WP_002354875.1 beta-phosphoglucomutase -
DR75_RS10165 (DR75_1876) 1918768..1919362 + 595 Protein_1829 hypothetical protein -
DR75_RS15720 1919603..1919746 - 144 WP_002392696.1 putative holin-like toxin Toxin
- 1919922..1920066 + 145 - - Antitoxin
DR75_RS15725 1920496..1920690 + 195 Protein_1831 CPBP family intramembrane metalloprotease -
DR75_RS10170 (DR75_1878) 1920743..1921714 - 972 WP_002381060.1 ribose-phosphate diphosphokinase -
DR75_RS10175 (DR75_1879) 1921889..1922326 - 438 WP_002354871.1 peptide-methionine (R)-S-oxide reductase MsrB -
DR75_RS10180 (DR75_1880) 1922459..1923013 - 555 WP_002354869.1 septum formation protein Maf -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5297.43 Da        Isoelectric Point: 10.6867

>T47597 WP_002392696.1 NZ_CP008816:c1919746-1919603 [Enterococcus faecalis ATCC 29212]
MSVLPKFTERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Download         Length: 144 bp

>T47597 NZ_CP008816:c1919746-1919603 [Enterococcus faecalis ATCC 29212]
ATGAGCGTACTTCCAAAATTTACAGAAAGGAGAGGCCTTTTGTCAGCATATGAAACAATTCAGACGATCCTAGGGTTTGG
TATGTTTACCATTGCTTTGATTGCACTGATTGTGAAATTGCTTAAAAATGACAATAAAAAATAA

Antitoxin


Download         Length: 145 bp

>AT47597 NZ_CP008816:1919922-1920066 [Enterococcus faecalis ATCC 29212]
TTGTGCTATAATGAAAACGAAAAGAGAGATATGCTTCAACATACCTCTCTGATGCAGAGCCGTTTAAGACGGTGACCGAT
TTTGTTACAAAAAATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTATTGTCATTTTTAACA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S4BYM2

Antitoxin

Download structure file

References