Detailed information of TA system TA047590

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1847268..1847554
• Replicon: chromosome
• Accession: NZ_CP008816
• Organism: Enterococcus faecalis ATCC 29212

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: DR75_RS09820
• Protein ID: WP_002393909.1
• Coordinates: 1847426..1847554 (-)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1847268..1847477 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DR75_RS09790 (DR75_1804)	1842518..1843471	-	954	WP_002359060.1	siderophore ABC transporter substrate-binding protein	-
DR75_RS09795 (DR75_1805)	1843510..1844265	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
DR75_RS09800 (DR75_1806)	1844262..1845227	-	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
DR75_RS09805 (DR75_1807)	1845224..1846171	-	948	WP_002404023.1	iron chelate uptake ABC transporter family permease subunit	-
DR75_RS09810 (DR75_1808)	1846356..1846808	+	453	WP_002354958.1	YueI family protein	-
DR75_RS09815	1846993..1847120	-	128	Protein_1760	putative holin-like toxin	-
-	1847268..1847477	+	210	-	-	Antitoxin
DR75_RS09820	1847426..1847554	-	129	WP_002393909.1	hypothetical protein	Toxin
DR75_RS09825 (DR75_1809)	1847717..1849987	-	2271	WP_033072596.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
DR75_RS09830 (DR75_1810)	1850158..1850658	+	501	WP_002354954.1	cysteine hydrolase	-
DR75_RS09835 (DR75_1811)	1851205..1852101	+	897	WP_002365354.1	YitT family protein	-
DR75_RS09840 (DR75_1812)	1852152..1852550	-	399	WP_002354951.1	glyoxalase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (11-42)

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4743.64 Da
• Isoelectric Point: 5.6470

>T47590 WP_002393909.1 NZ_CP008816:c1847554-1847426 [Enterococcus faecalis ATCC 29212]
MHFNERSIFLSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 129 bp

>T47590 NZ_CP008816:c1847554-1847426 [Enterococcus faecalis ATCC 29212]
ATGCACTTTAACGAAAGGAGCATTTTTTTGTCAATCGAAGCGGCATTGGAATTGATGATTAGTTTTGCAGCGTTTGTTGC
ACTACTGATTTTCGGTATCCTTGAAGCAACGAAAAACGATAAAAAATAA

Antitoxin

Nucleotide

• Length: 210 bp

>AT47590 NZ_CP008816:1847268-1847477 [Enterococcus faecalis ATCC 29212]
TTCCATTTTAAATAGAATTATGCTATTATGAAAATGAAAAGAGAGATATGCTACTACATACCTCTCCTTTATACCAACAC
CAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTTTTGTTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTT
ATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGAAAATCAGTAGTGCA

Structures

Antitoxin