47574

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 5462689..5463101 Replicon chromosome
Accession NZ_CP008805
Organism Escherichia coli O157:H7 str. SS17

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag SS17_RS28145 Protein ID WP_000132630.1
Coordinates 5462689..5463030 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 5463025..5463101 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SS17_RS34215 5458258..5458458 + 201 WP_001310455.1 hypothetical protein -
SS17_RS28130 5458701..5460113 - 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -
SS17_RS28135 5460290..5460454 + 165 WP_038431159.1 DUF1127 domain-containing protein -
SS17_RS28140 5460549..5462642 + 2094 WP_010905017.1 DUF262 domain-containing protein -
SS17_RS28145 5462689..5463030 - 342 WP_000132630.1 endoribonuclease SymE Toxin
- 5463025..5463101 + 77 NuclAT_14 - Antitoxin
- 5463025..5463101 + 77 NuclAT_14 - Antitoxin
- 5463025..5463101 + 77 NuclAT_14 - Antitoxin
- 5463025..5463101 + 77 NuclAT_14 - Antitoxin
- 5463025..5463101 + 77 NuclAT_15 - Antitoxin
- 5463025..5463101 + 77 NuclAT_15 - Antitoxin
- 5463025..5463101 + 77 NuclAT_15 - Antitoxin
- 5463025..5463101 + 77 NuclAT_15 - Antitoxin
SS17_RS28150 5463251..5465005 - 1755 WP_000110082.1 restriction endonuclease subunit S -
SS17_RS28155 5465005..5466474 - 1470 WP_001302468.1 type I restriction-modification system subunit M -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 5452183..5470902 18719


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T47574 WP_000132630.1 NZ_CP008805:c5463030-5462689 [Escherichia coli O157:H7 str. SS17]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

>T47574 NZ_CP008805:c5463030-5462689 [Escherichia coli O157:H7 str. SS17]
ATGACTGATACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCAATTAACCGTGAGTTA
TGCGAGTCGTTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CCGGCACGGTGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGCCGAGAGCGAA
CTGATGCAGTCGCTGCGCCAGGTGTGCAAGCTGTCGGCGCGTAAACAAAGGCAGGTGCAGGAGTTTATTGGGGTGATTGC
GGGTAAACAGAAAGTTGCCTGA

Antitoxin


Download         Length: 77 bp

>AT47574 NZ_CP008805:5463025-5463101 [Escherichia coli O157:H7 str. SS17]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References