Detailed information of TA system TA047543

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 1176972..1177197
• Replicon: chromosome
• Accession: NZ_CP008805
• Organism: Escherichia coli O157:H7 str. SS17

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: -
• Locus tag: SS17_RS05625
• Protein ID: WP_000813263.1
• Coordinates: 1177042..1177197 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	1176972..1177030 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SS17_RS05600	1172247..1173338	+	1092	WP_001205823.1	hypothetical protein	-
SS17_RS05605	1173345..1174091	+	747	WP_000788745.1	ATP-binding protein	-
SS17_RS05610	1174113..1174883	+	771	WP_000450992.1	DUF1627 domain-containing protein	-
SS17_RS05615	1174899..1175312	+	414	WP_001151233.1	DUF977 family protein	-
SS17_RS05620	1175664..1176437	-	774	WP_000160654.1	alpha/beta hydrolase	-
-	1176972..1177030	-	59	-	-	Antitoxin
SS17_RS05625	1177042..1177197	+	156	WP_000813263.1	type I toxin-antitoxin system toxin HokD	Toxin
SS17_RS32010	1177365..1177643	+	279	WP_001341388.1	hypothetical protein	-
SS17_RS05635	1177645..1178694	+	1050	WP_001265172.1	DUF968 domain-containing protein	-
SS17_RS05640	1178707..1179078	+	372	WP_001217436.1	RusA family crossover junction endodeoxyribonuclease	-
SS17_RS05645	1179068..1179439	+	372	WP_000090264.1	antitermination protein	-
SS17_RS05650	1179591..1180409	+	819	WP_000265265.1	CPBP family intramembrane metalloprotease	-
SS17_RS05655	1180696..1180892	+	197	Protein_1067	TrmB family transcriptional regulator	-
SS17_RS05660	1181030..1181743	+	714	WP_000261909.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5722.86 Da
• Isoelectric Point: 6.1531

>T47543 WP_000813263.1 NZ_CP008805:1177042-1177197 [Escherichia coli O157:H7 str. SS17]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRVRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T47543 NZ_CP008805:1177042-1177197 [Escherichia coli O157:H7 str. SS17]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAGTCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT47543 NZ_CP008805:c1177030-1176972 [Escherichia coli O157:H7 str. SS17]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTAGATTTGCCGTTCATAGATTGAGCCTCA

Structures

Antitoxin