Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 286482..287021 Replicon chromosome
Accession NZ_CP008805
Organism Escherichia coli O157:H7 str. SS17

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag SS17_RS01325 Protein ID WP_001303998.1
Coordinates 286482..286742 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID C3TP07
Locus tag SS17_RS01330 Protein ID WP_000729705.1
Coordinates 286761..287021 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SS17_RS01310 284165..284743 + 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -
SS17_RS01315 284848..285615 + 768 WP_001301698.1 class II glutamine amidotransferase -
SS17_RS01320 285586..286326 - 741 WP_001225679.1 murein L,D-transpeptidase -
SS17_RS01325 286482..286742 - 261 WP_001303998.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
SS17_RS01330 286761..287021 - 261 WP_000729705.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
SS17_RS01335 287207..287980 + 774 WP_000543891.1 C40 family peptidase -
SS17_RS32920 288156..288653 + 498 Protein_251 REP-associated tyrosine transposase RayT -
SS17_RS01345 288798..290510 - 1713 Protein_252 flagellar biosynthesis protein FlhA -
SS17_RS01350 290482..291267 + 786 WP_000207556.1 putative lateral flagellar export/assembly protein LafU -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10026.71 Da        Isoelectric Point: 10.3188

>T47538 WP_001303998.1 NZ_CP008805:c286742-286482 [Escherichia coli O157:H7 str. SS17]
MNSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLRFERTGT
HAALFG

Download         Length: 261 bp

>T47538 NZ_CP008805:c286742-286482 [Escherichia coli O157:H7 str. SS17]
TTGAACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAATAAATTGAAATATCTTAT
GACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAGGTTCATGGAAAGGTTATC
GCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGATTTGAGAGAACTGGAACT
CACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9377.74 Da        Isoelectric Point: 5.0758

>AT47538 WP_000729705.1 NZ_CP008805:c287021-286761 [Escherichia coli O157:H7 str. SS17]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGV

Download         Length: 261 bp

>AT47538 NZ_CP008805:c287021-286761 [Escherichia coli O157:H7 str. SS17]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References