Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3244867..3245560 Replicon chromosome
Accession NZ_CP008801
Organism Escherichia coli KLY

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag HQ24_RS16110 Protein ID WP_000415584.1
Coordinates 3245264..3245560 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag HQ24_RS16105 Protein ID WP_000650107.1
Coordinates 3244867..3245262 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HQ24_RS16095 3240731..3242989 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
HQ24_RS16100 3243127..3244734 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
HQ24_RS16105 3244867..3245262 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
HQ24_RS16110 3245264..3245560 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
HQ24_RS16115 3245765..3246247 - 483 WP_000183505.1 transcriptional regulator -
HQ24_RS16120 3246300..3246692 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
HQ24_RS16125 3246844..3247503 + 660 WP_001221495.1 two-component system response regulator QseB -
HQ24_RS16130 3247500..3248849 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
HQ24_RS16135 3248895..3249227 - 333 WP_000917684.1 DUF2645 family protein -
HQ24_RS16140 3249546..3250127 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
HQ24_RS16145 3250158..3250472 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T47524 WP_000415584.1 NZ_CP008801:c3245560-3245264 [Escherichia coli KLY]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T47524 NZ_CP008801:c3245560-3245264 [Escherichia coli KLY]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT47524 WP_000650107.1 NZ_CP008801:c3245262-3244867 [Escherichia coli KLY]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT47524 NZ_CP008801:c3245262-3244867 [Escherichia coli KLY]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References