Detailed information of TA system TA047420

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 3062154..3062709
• Replicon: chromosome
• Accession: NZ_CP008762
• Organism: Paraburkholderia xenovorans LB400

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: Q13P61
• Locus tag: DR64_RS41715
• Protein ID: WP_011491474.1
• Coordinates: 3062154..3062405 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q13P62
• Locus tag: DR64_RS41720
• Protein ID: WP_011491473.1
• Coordinates: 3062416..3062709 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DR64_RS41695	3057484..3059088	+	1605	WP_011491478.1	iron ABC transporter permease	-
DR64_RS41700	3059117..3060175	+	1059	WP_011491477.1	ABC transporter ATP-binding protein	-
DR64_RS41705	3060160..3061050	-	891	WP_011491476.1	LysR family transcriptional regulator	-
DR64_RS41710	3061153..3062073	+	921	WP_011491475.1	DMT family transporter	-
DR64_RS41715	3062154..3062405	-	252	WP_011491474.1	Txe/YoeB family addiction module toxin	Toxin
DR64_RS41720	3062416..3062709	-	294	WP_011491473.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
DR64_RS41725	3062975..3064273	-	1299	WP_011491472.1	MFS transporter	-
DR64_RS41730	3064454..3065227	+	774	WP_011491471.1	GntR family transcriptional regulator	-
DR64_RS41735	3065237..3066898	+	1662	WP_011491470.1	malonate decarboxylase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9985.43 Da
• Isoelectric Point: 7.8124

>T47420 WP_011491474.1 NZ_CP008762:c3062405-3062154 [Paraburkholderia xenovorans LB400]
MFTDDAWDDYLYWQETDRKVVRKINTLLEECRRDPYRGTGKPEALMGSMSGLWSRRITLADRLVYLPRDGKIYVIAFRFH
YDC

Nucleotide

• Length: 252 bp

>T47420 NZ_CP008762:c3062405-3062154 [Paraburkholderia xenovorans LB400]
ATGTTCACCGACGACGCGTGGGACGATTACCTGTATTGGCAAGAGACCGACCGGAAGGTCGTGCGCAAGATCAACACGCT
GCTGGAGGAGTGCCGGCGCGATCCTTATCGCGGTACGGGGAAACCGGAGGCGTTGATGGGCAGCATGAGCGGATTGTGGT
CTCGGCGTATCACGCTGGCCGACCGTCTTGTCTACTTGCCGCGAGACGGAAAGATCTACGTGATCGCCTTTCGCTTCCAC
TACGACTGCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10686.15 Da
• Isoelectric Point: 9.0641

>AT47420 WP_011491473.1 NZ_CP008762:c3062709-3062416 [Paraburkholderia xenovorans LB400]
MNVLTYSEARAGFKQAMDDVCRDHIPMLITRQTGENVVMVSLADFNAMQETLYLLSSSKNAQRLARSIAQLNAGGATARE
LLTDEQTQKPQRGGRKG

Nucleotide

• Length: 294 bp

>AT47420 NZ_CP008762:c3062709-3062416 [Paraburkholderia xenovorans LB400]
ATGAACGTCCTTACTTATAGCGAGGCGCGTGCCGGCTTCAAGCAGGCGATGGACGACGTCTGCCGCGATCACATACCCAT
GCTGATCACGAGGCAGACGGGCGAAAACGTGGTGATGGTTTCGCTCGCGGATTTCAATGCGATGCAGGAGACCTTGTATC
TGTTGAGTTCGTCGAAGAACGCCCAGCGGCTCGCCCGATCTATCGCTCAACTGAACGCCGGCGGTGCGACTGCGCGTGAA
CTGCTGACCGATGAACAGACACAGAAGCCGCAACGAGGAGGCCGCAAAGGCTGA

Structures

Toxin

• AlphaFold DB: Q13P61

Antitoxin

• AlphaFold DB: Q13P62