47327

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA-HipA
Location 801500..802848 Replicon chromosome
Accession NZ_CP008740
Organism Haemophilus influenzae 2019

Toxin (Protein)


Gene name HipT Uniprot ID A0A808U3D1
Locus tag C645_RS04150 Protein ID WP_046067657.1
Coordinates 801500..802531 (-) Length 344 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID A0A2S9RZQ1
Locus tag C645_RS04155 Protein ID WP_005672747.1
Coordinates 802528..802848 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C645_RS04140 798020..799765 + 1746 WP_046067655.1 ABC transporter ATP-binding protein/permease -
C645_RS04145 799758..801416 + 1659 WP_046067656.1 thiol reductant ABC exporter subunit CydC -
C645_RS04150 801500..802531 - 1032 WP_046067657.1 type II toxin-antitoxin system HipA family toxin Toxin
C645_RS04155 802528..802848 - 321 WP_005672747.1 type II toxin-antitoxin system HipA family toxin Antitoxin
C645_RS04160 802836..803144 - 309 WP_005661200.1 helix-turn-helix domain-containing protein -
C645_RS04165 803350..804351 - 1002 WP_046067658.1 class II fructose-bisphosphatase -
C645_RS04170 804513..804731 + 219 WP_005650820.1 cell division protein ZapB -
C645_RS04175 804829..805269 + 441 WP_046067659.1 FMN-binding protein MioC -
C645_RS04180 805266..805700 + 435 WP_046067660.1 D-tyrosyl-tRNA(Tyr) deacylase -
C645_RS10295 805965..806132 + 168 WP_165590253.1 hypothetical protein -
C645_RS04185 806202..806678 - 477 WP_021034585.1 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase -
C645_RS04190 806675..807352 - 678 WP_046067661.1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase -
C645_RS04195 807352..807630 - 279 WP_046067662.1 cell division protein FtsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-290)

Antitoxin

HipA, N-terminal subdomain 1

(9-101)


Sequences

Toxin        


Download         Length: 344 a.a.        Molecular weight: 39774.27 Da        Isoelectric Point: 6.5048

>T47327 WP_046067657.1 NZ_CP008740:c802531-801500 [Haemophilus influenzae 2019]
MNFCRILLKPLKKNEVHSGYSTKGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMHIMKELGFDVPENGLVSFAGEQNQKEFAFVIKRFDRDEQQTAIHQEQLDGAMNIRDK
YGKIGADNEQYVSYERVAKFILQHTENHLAQQQEIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEITQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLTLLNVLNEPEL

Download         Length: 1032 bp

>T47327 NZ_CP008740:c802531-801500 [Haemophilus influenzae 2019]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGTTCATTCTGGTTACAGCACAAAAGGTTTGCATTA
TCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACATGCCACCATGCACATTATGAA
AGAATTAGGGTTTGACGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCAGAAGGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATGAACAGCAAACAGCGATTCATCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCTGATAATGAGCAATATGTAAGTTATGAGCGCGTTGCTAAGTTTATTTTACAACACACTGAAAA
TCATTTAGCTCAGCAACAAGAGATTTTCCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAATAGTCATCCAAAACTTGCTCCAATTTATGACTTTGTATCGGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCACGAGAAGAGGGTAATGCCACACTCGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTACACAAGAAAAGGAAAAGGTGGAGCAGATTTATTCACAATCCTTTATGCCGCAACCACAT
ATTGATTGTGTACTGAAAACTTATCGCAAGCGTTTAACGTTACTTAACGTATTAAATGAACCTGAGCTATAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12453.12 Da        Isoelectric Point: 5.9670

>AT47327 WP_005672747.1 NZ_CP008740:c802848-802528 [Haemophilus influenzae 2019]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Download         Length: 321 bp

>AT47327 NZ_CP008740:c802848-802528 [Haemophilus influenzae 2019]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A808U3D1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9RZQ1

References