47320

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1000092..1000687 Replicon chromosome
Accession NZ_CP008739
Organism Pseudomonas aeruginosa VRFPA04

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag P797_RS32025 Protein ID WP_072018006.1
Coordinates 1000092..1000370 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag P797_RS04570 Protein ID WP_003133769.1
Coordinates 1000382..1000687 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P797_RS04555 995518..996756 + 1239 WP_003111578.1 C69 family dipeptidase -
P797_RS04560 996818..997465 + 648 WP_003095021.1 carbonate dehydratase -
P797_RS04565 997535..999763 - 2229 WP_003133778.1 TonB-dependent receptor -
P797_RS32025 1000092..1000370 + 279 WP_072018006.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P797_RS04570 1000382..1000687 + 306 WP_003133769.1 HigA family addiction module antidote protein Antitoxin
P797_RS04580 1001083..1002183 - 1101 WP_003099270.1 redox-regulated ATPase YchF -
P797_RS04585 1002224..1002808 - 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
P797_RS04590 1002850..1003464 - 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
P797_RS04595 1003581..1004522 - 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
P797_RS04605 1004689..1005537 + 849 WP_025297598.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(11-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10593.14 Da        Isoelectric Point: 7.2157

>T47320 WP_072018006.1 NZ_CP008739:1000092-1000370 [Pseudomonas aeruginosa VRFPA04]
MILTFCCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T47320 NZ_CP008739:1000092-1000370 [Pseudomonas aeruginosa VRFPA04]
ATGATTCTGACCTTTTGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGGTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAACGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT47320 WP_003133769.1 NZ_CP008739:1000382-1000687 [Pseudomonas aeruginosa VRFPA04]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT47320 NZ_CP008739:1000382-1000687 [Pseudomonas aeruginosa VRFPA04]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAACGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTCGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCACGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References