Detailed information of TA system TA047311

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 2517450..2518149
• Replicon: chromosome
• Accession: NZ_CP008729
• Organism: Burkholderia multivorans strain DDS 15A-1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: DM80_RS15805
• Protein ID: WP_048804722.1
• Coordinates: 2517853..2518149 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: DM80_RS15800
• Protein ID: WP_048804721.1
• Coordinates: 2517450..2517851 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DM80_RS15780	2513152..2514504	-	1353	WP_006413139.1	LLM class flavin-dependent oxidoreductase	-
DM80_RS15785	2514501..2515562	-	1062	WP_048804719.1	LLM class flavin-dependent oxidoreductase	-
DM80_RS15790	2515594..2516535	-	942	WP_006397013.1	ABC transporter substrate-binding protein	-
DM80_RS15795	2516601..2517161	-	561	WP_048804720.1	GNAT family N-acetyltransferase	-
DM80_RS15800	2517450..2517851	-	402	WP_048804721.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
DM80_RS15805	2517853..2518149	-	297	WP_048804722.1	type II toxin-antitoxin system MqsR family toxin	Toxin
DM80_RS15810	2518269..2519303	-	1035	WP_048804723.1	succinylglutamate desuccinylase/aspartoacylase family protein	-
DM80_RS15815	2519406..2519678	-	273	WP_012216969.1	hypothetical protein	-
DM80_RS15820	2519884..2521428	-	1545	WP_167541822.1	sensor domain-containing diguanylate cyclase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-97)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11185.07 Da
• Isoelectric Point: 9.1122

>T47311 WP_048804722.1 NZ_CP008729:c2518149-2517853 [Burkholderia multivorans]
MEKRTPHCKLPRVKALVEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPCTMRGDV
YLKLTVVDDVLIVSFKER

Nucleotide

• Length: 297 bp

>T47311 NZ_CP008729:c2518149-2517853 [Burkholderia multivorans]
ATGGAAAAGAGAACGCCGCATTGCAAGCTGCCGCGCGTCAAGGCGCTGGTCGAAGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCAGATGGGCTTCACCGAAGCGGAAACGATCGACGTGGTAAGGGCGCTGACACCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGCACGATGCGCGGCGACGTG
TATCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14521.68 Da
• Isoelectric Point: 7.0834

>AT47311 WP_048804721.1 NZ_CP008729:c2517851-2517450 [Burkholderia multivorans]
MKCPACGAATLIRDTRDIPYTYKGESTVIPHVTGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKLLDRHPDLLDEVRAA

Nucleotide

• Length: 402 bp

>AT47311 NZ_CP008729:c2517851-2517450 [Burkholderia multivorans]
ATGAAATGTCCTGCATGCGGCGCCGCCACGCTGATCCGCGATACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCACGTCACCGGCGAGTTTTGCCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAATCGGCAAGTGAATGCGACACTCGTCGATCCGAAGTTCATTGCGACGGTGCGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCGCTCGTGAAGCTGCTGAAGCTTCTCGACCGTCATCCCGATCTGCTCGACGAAGTGCGCGCGGCAT
AA