Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3455588..3456245 Replicon chromosome
Accession NZ_CP008726
Organism Burkholderia oklahomensis strain EO147

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DM82_RS15520 Protein ID WP_010111813.1
Coordinates 3455913..3456245 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DM82_RS34085 Protein ID WP_010111811.1
Coordinates 3455588..3455905 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM82_RS15495 3451257..3452284 - 1028 Protein_3060 IS21 family transposase -
DM82_RS15500 3452308..3453330 + 1023 WP_081956034.1 site-specific integrase -
DM82_RS15505 3453479..3454801 + 1323 WP_038802795.1 IS5 family transposase -
DM82_RS34080 3455083..3455388 - 306 WP_081464427.1 DUF3892 domain-containing protein -
DM82_RS34085 3455588..3455905 - 318 WP_010111811.1 helix-turn-helix domain-containing protein Antitoxin
DM82_RS15520 3455913..3456245 - 333 WP_010111813.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM82_RS15525 3456287..3456874 - 588 WP_038801761.1 site-specific integrase -
DM82_RS15530 3457222..3458001 - 780 WP_038801760.1 hypothetical protein -
DM82_RS15535 3458452..3458928 - 477 WP_038802796.1 hypothetical protein -
DM82_RS15540 3459237..3460601 - 1365 WP_038802797.1 type II secretory pathway protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3433051..3465344 32293


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-97)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12863.95 Da        Isoelectric Point: 10.3619

>T47301 WP_010111813.1 NZ_CP008726:c3456245-3455913 [Burkholderia oklahomensis]
MKFDWTIVYYNERVKRDVFAFPAGILADYLRLLDLMQEFGADLRMPHSRAMGNGLFELRPKGREGIGRVFYCTHVGRQVV
VLHSFVKKTQETPQHELRIAQARLREVRNG

Download         Length: 333 bp

>T47301 NZ_CP008726:c3456245-3455913 [Burkholderia oklahomensis]
ATGAAATTCGATTGGACGATTGTCTACTATAACGAACGGGTGAAGCGCGACGTGTTCGCGTTCCCGGCAGGGATTCTCGC
GGACTACCTCCGGCTGTTGGATCTGATGCAGGAGTTCGGGGCAGATCTGCGGATGCCGCACTCCCGAGCAATGGGTAACG
GGTTGTTTGAGTTGCGCCCCAAGGGGAGGGAAGGTATCGGTCGAGTGTTCTATTGCACGCATGTGGGGCGGCAAGTCGTT
GTGCTGCACTCCTTCGTTAAGAAGACACAGGAAACACCGCAACATGAATTGCGGATCGCCCAAGCACGTTTAAGAGAGGT
GCGTAATGGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11235.76 Da        Isoelectric Point: 10.2231

>AT47301 WP_010111811.1 NZ_CP008726:c3455905-3455588 [Burkholderia oklahomensis]
VKRARAEGFNPVPHTADDTARLLAGRNVKAAYDALEDEYTALRAILSARREAGLTQAQIAERMGTTASAVSRLEASLSSE
KHSPSFATLRKYAAACGKKLVISFA

Download         Length: 318 bp

>AT47301 NZ_CP008726:c3455905-3455588 [Burkholderia oklahomensis]
GTGAAGCGTGCTCGCGCTGAGGGATTCAATCCGGTTCCGCATACGGCGGACGACACGGCGCGTCTGCTCGCCGGTCGGAA
TGTCAAGGCGGCGTATGACGCTTTGGAGGATGAGTACACCGCGTTGCGCGCTATCTTGTCTGCGCGGCGCGAAGCTGGTT
TGACGCAGGCACAGATTGCGGAGCGTATGGGAACGACCGCATCGGCGGTTTCGCGGCTTGAGGCATCTCTGTCGAGTGAA
AAGCACTCACCGTCATTTGCGACGCTGCGGAAATATGCTGCCGCATGCGGGAAGAAACTTGTAATTTCGTTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References