Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-MqsA
Location 2594925..2595580 Replicon chromosome
Accession NZ_CP008726
Organism Burkholderia oklahomensis strain EO147

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DM82_RS37960 Protein ID WP_010105746.1
Coordinates 2594925..2595269 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DM82_RS37965 Protein ID WP_010105748.1
Coordinates 2595266..2595580 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM82_RS11475 2590265..2590723 + 459 WP_010105738.1 hypothetical protein -
DM82_RS11480 2591018..2592301 + 1284 WP_010105739.1 glutamate-1-semialdehyde 2,1-aminomutase -
DM82_RS11485 2592330..2593466 + 1137 WP_038800986.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
DM82_RS11490 2593481..2594110 + 630 WP_010105743.1 riboflavin synthase -
DM82_RS11495 2594264..2594764 - 501 WP_038800987.1 hypothetical protein -
DM82_RS37960 2594925..2595269 + 345 WP_010105746.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM82_RS37965 2595266..2595580 + 315 WP_010105748.1 transcriptional regulator Antitoxin
DM82_RS11510 2596014..2597150 + 1137 WP_010105760.1 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
DM82_RS11515 2597231..2597749 + 519 WP_010105762.1 6,7-dimethyl-8-ribityllumazine synthase -
DM82_RS11520 2597746..2598183 + 438 WP_010105764.1 transcription antitermination factor NusB -
DM82_RS11525 2598245..2599438 + 1194 WP_010105766.1 pyridoxal phosphate-dependent aminotransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(45-90)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13412.31 Da        Isoelectric Point: 9.1937

>T47300 WP_010105746.1 NZ_CP008726:2594925-2595269 [Burkholderia oklahomensis]
MEATFIELPTFSRERENYLADDEYAVLQKELLANPEAGDMIKGAGGLRKLRFADKRRQKGKRGGLRVIYYYWVSGYQFWL
FTLYDKDEMADLSSDERKAFAKLLEREVTIRSKQ

Download         Length: 345 bp

>T47300 NZ_CP008726:2594925-2595269 [Burkholderia oklahomensis]
ATGGAAGCGACCTTCATTGAACTGCCGACGTTTTCCCGTGAACGCGAGAACTACCTGGCGGATGACGAGTACGCCGTCCT
GCAGAAAGAGCTGCTGGCCAATCCCGAGGCTGGCGACATGATCAAGGGAGCCGGCGGTCTGCGGAAGTTGAGGTTCGCCG
ACAAACGCCGCCAGAAAGGCAAACGCGGTGGCCTACGGGTGATCTATTACTACTGGGTCAGCGGTTATCAATTCTGGTTG
TTCACACTGTACGACAAGGATGAAATGGCAGACCTCTCCAGTGACGAGCGCAAAGCCTTCGCTAAGCTACTGGAAAGAGA
GGTCACGATACGGAGCAAGCAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11560.41 Da        Isoelectric Point: 10.3388

>AT47300 WP_010105748.1 NZ_CP008726:2595266-2595580 [Burkholderia oklahomensis]
MKKRNLFAELTEGLDALAAEREGKITLRKIKADVPDALEVSPAEIKAVREASHASQAVMARSLRINVRTYQNWEQGKAKP
NAQAATLIRLVAKHPETLQMLETL

Download         Length: 315 bp

>AT47300 NZ_CP008726:2595266-2595580 [Burkholderia oklahomensis]
ATGAAGAAGCGAAATCTGTTTGCTGAATTGACCGAGGGTCTCGATGCCCTTGCTGCCGAGCGCGAAGGGAAAATCACGCT
GCGCAAGATCAAGGCCGATGTGCCCGATGCGCTCGAAGTTTCGCCGGCAGAAATCAAGGCCGTGCGTGAAGCCTCTCACG
CGTCGCAAGCCGTCATGGCCCGAAGCCTGCGCATCAATGTGCGCACGTATCAGAATTGGGAACAAGGCAAGGCCAAGCCC
AACGCACAAGCGGCCACGCTGATCCGACTGGTCGCCAAGCACCCGGAAACGCTTCAGATGCTGGAAACGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References