Detailed information of TA system TA047278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 22237..22895
• Replicon: plasmid p1AB5075
• Accession: NZ_CP008707
• Organism: Acinetobacter baumannii strain AB5075-UW

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: ABUW_RS19215
• Protein ID: WP_000312250.1
• Coordinates: 22536..22895 (-)
• Length: 120 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: ABUW_RS19210
• Protein ID: WP_001096429.1
• Coordinates: 22237..22536 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ABUW_RS19170	17262..18542	+	1281	WP_001093570.1	hypothetical protein	-
ABUW_RS19175	18647..18904	+	258	WP_000834290.1	hypothetical protein	-
ABUW_RS19180	18909..19481	+	573	WP_000443897.1	hypothetical protein	-
ABUW_RS19185	19457..19636	+	180	WP_000387630.1	hypothetical protein	-
ABUW_RS19190	19653..20282	+	630	WP_000701003.1	hypothetical protein	-
ABUW_RS19195	20322..20540	+	219	WP_001043201.1	hypothetical protein	-
ABUW_RS19200	20560..21114	+	555	WP_000790084.1	hypothetical protein	-
ABUW_RS19205	21164..21700	+	537	WP_000731978.1	hypothetical protein	-
ABUW_RS19210	22237..22536	-	300	WP_001096429.1	helix-turn-helix transcriptional regulator	Antitoxin
ABUW_RS19215	22536..22895	-	360	WP_000312250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ABUW_RS19220	23096..23662	+	567	WP_000710385.1	hypothetical protein	-
ABUW_RS19225	23711..23893	+	183	WP_000373385.1	hypothetical protein	-
ABUW_RS19230	23960..24658	+	699	WP_000873188.1	hypothetical protein	-
ABUW_RS19235	24797..25180	+	384	WP_000654348.1	hypothetical protein	-
ABUW_RS19240	25247..25726	+	480	Protein_40	hypothetical protein	-
ABUW_RS20015	26167..26574	+	408	Protein_41	Mu transposase C-terminal domain-containing protein	-
ABUW_RS20020	26577..27569	+	993	WP_001381192.1	TniB family NTP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	sul1 / qacE / dfrA7 / aac(6')-Ib / blaGES-11 / aph(6)-Id / aph(3'')-Ib / aadA2 / cmlA1 / ant(2'')-Ia / aph(3')-VIa	-	1..83610	83610

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-109)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-88)

Sequences

Toxin

Protein

• Length: 120 a.a.
• Molecular weight: 13751.62 Da
• Isoelectric Point: 4.8212

>T47278 WP_000312250.1 NZ_CP008707:c22895-22536 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Nucleotide

• Length: 360 bp

>T47278 NZ_CP008707:c22895-22536 [Acinetobacter baumannii]
ATGGCTTGGGATGTAGAAACAACAGAACTTTTTGATTCTTGGTTGGCAGAACAAGATGAAAATGCTCAAGATAAAATCTT
AGCGTCTTTGCTTGTTTTGTCAGAACTGGGGCCAAATCTAGGCCGGCCTCATGTTGATACTATTAAAGAATCAAAATATC
CGAACATGAAAGAGATACGTGTGCAAGTTAAAGGTCATCCGATCCGTGGTTTCTTTGCATTTGATCCAGAACGTAAAGCC
ATTGTTTTGTGTGCTGGAGATAAGAAAGGGCTAAATGAAAAAGCCTTTTATAAAGAAATGATCAAGATTGCAGATGAACA
ATATGAGCAATATTTACGTGATAATTACGGAGATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11012.93 Da
• Isoelectric Point: 10.4856

>AT47278 WP_001096429.1 NZ_CP008707:c22536-22237 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Nucleotide

• Length: 300 bp

>AT47278 NZ_CP008707:c22536-22237 [Acinetobacter baumannii]
ATGGCTAAATTAAACGATATAATTTCAAAACGCTCACCTGAAAGCCAACAACGCATCAAGAAAATGGCAAATCAAATGCT
ATTGGATATTAACCTATCGAACCTACGGGAAGAGTTAAAAATATCTCAAGCTGAAATTGCAAAAAATCTAGGTGTAAGCC
AAGCTGCTATTTCAAAACGTGAAAAATTAGGTAAAGATCTTAAGATTTCATCATTAAAAGAATATGTTGAAGCTATGGGT
GGCAAAGTAAGGTTAGATGTTGAGTTACCTAACGGAAAGCATGTTGCTATATCTATTTAA