Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 419461..420155 Replicon chromosome
Accession NZ_CP008696
Organism Pseudomonas chlororaphis strain PA23

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EY04_RS01765 Protein ID WP_009046630.1
Coordinates 419461..419757 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A554PLA7
Locus tag EY04_RS01770 Protein ID WP_009046631.1
Coordinates 419754..420155 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EY04_RS01730 414995..415540 - 546 WP_028683761.1 membrane protein -
EY04_RS01735 415537..415791 - 255 WP_007926835.1 acyl carrier protein -
EY04_RS01740 415801..416061 - 261 WP_007926834.1 acyl carrier protein -
EY04_RS01745 416036..416851 - 816 WP_009046627.1 1-acyl-sn-glycerol-3-phosphate acyltransferase -
EY04_RS01750 416827..417558 - 732 WP_038630426.1 beta-ketoacyl synthase chain length factor -
EY04_RS01755 417892..418662 + 771 WP_007926828.1 ParA family protein -
EY04_RS01760 418788..419222 - 435 WP_016704469.1 thioredoxin TrxC -
EY04_RS01765 419461..419757 + 297 WP_009046630.1 type II toxin-antitoxin system HigB family toxin Toxin
EY04_RS01770 419754..420155 + 402 WP_009046631.1 transcriptional regulator Antitoxin
EY04_RS01775 420159..421622 - 1464 WP_016704471.1 YdiU family protein -
EY04_RS01780 421671..425021 - 3351 WP_009046633.1 mechanosensitive channel MscK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-90)

Antitoxin

Antitoxin HigA

(15-133)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11489.27 Da        Isoelectric Point: 10.5069

>T47219 WP_009046630.1 NZ_CP008696:419461-419757 [Pseudomonas chlororaphis]
MHIITAKRIWEAKSRWPQSANALETWYRKVKSLNPADFAAIKAVFPATDKVGAFHVFDIGGNKLRIIAVVRYEVRRLYIR
HVLDHHEYDKGRWKEETG

Download         Length: 297 bp

>T47219 NZ_CP008696:419461-419757 [Pseudomonas chlororaphis]
ATGCATATCATCACCGCCAAACGAATCTGGGAGGCCAAGAGCCGCTGGCCACAATCGGCCAATGCGCTGGAGACCTGGTA
CAGAAAAGTCAAAAGCCTCAATCCGGCCGATTTTGCAGCCATCAAGGCAGTATTTCCGGCCACCGACAAAGTGGGGGCGT
TTCACGTCTTCGATATTGGCGGCAACAAGTTACGAATCATCGCCGTGGTGCGTTATGAGGTGCGACGTCTCTATATCAGA
CACGTGCTGGACCATCACGAATACGACAAGGGCAGGTGGAAGGAGGAGACCGGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14840.85 Da        Isoelectric Point: 4.4394

>AT47219 WP_009046631.1 NZ_CP008696:419754-420155 [Pseudomonas chlororaphis]
MNVLVKQAADHWHFVAPVLRKPNTEADYDALVAALDELLDLMGEDENHPVTSLVDIIGDWIEAYDEEHRPMPIASGVDVL
RSLMREHGLTQSDLPGVGAQSVVSEVLSGKRQLNLRQIRWLAERFGVSAEVFI

Download         Length: 402 bp

>AT47219 NZ_CP008696:419754-420155 [Pseudomonas chlororaphis]
ATGAACGTTCTGGTGAAGCAGGCGGCGGATCATTGGCATTTCGTGGCCCCTGTGTTGCGTAAACCCAATACTGAAGCCGA
TTACGATGCATTGGTCGCGGCGCTGGATGAACTGCTGGATCTCATGGGAGAGGACGAGAACCATCCAGTGACTTCGCTGG
TGGACATCATCGGCGATTGGATCGAAGCCTACGACGAAGAGCATCGACCGATGCCGATAGCCAGTGGCGTTGACGTCTTG
CGCTCCCTGATGCGCGAACACGGCCTGACCCAGAGTGATCTGCCAGGCGTGGGTGCGCAGTCGGTGGTTTCGGAAGTACT
GAGCGGCAAGCGCCAGCTCAACCTGCGACAGATCCGCTGGCTGGCCGAGCGCTTCGGTGTTTCGGCCGAGGTATTTATCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A554PLA7

References