Detailed information of TA system TA047147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/HipA-HipA
• Location: 584204..585552
• Replicon: chromosome
• Accession: NZ_CP007805
• Organism: Haemophilus influenzae CGSHiCZ412602

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: H733_RS02895
• Protein ID: WP_038439531.1
• Coordinates: 584204..585235 (-)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A806DF96
• Locus tag: H733_RS02900
• Protein ID: WP_020910207.1
• Coordinates: 585232..585552 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H733_RS02885	580693..582468	+	1776	WP_038439529.1	ABC transporter ATP-binding protein/permease	-
H733_RS02890	582461..584119	+	1659	WP_038439530.1	thiol reductant ABC exporter subunit CydC	-
H733_RS02895	584204..585235	-	1032	WP_038439531.1	type II toxin-antitoxin system HipA family toxin	Toxin
H733_RS02900	585232..585552	-	321	WP_020910207.1	type II toxin-antitoxin system HipA family toxin	Antitoxin
H733_RS02905	585540..585848	-	309	WP_005661200.1	helix-turn-helix domain-containing protein	-
H733_RS02910	586048..587049	-	1002	WP_038439532.1	class II fructose-bisphosphatase	-
H733_RS02915	587211..587429	+	219	WP_005650820.1	cell division protein ZapB	-
H733_RS02920	587523..587963	+	441	WP_005667635.1	FMN-binding protein MioC	-
H733_RS02925	587960..588394	+	435	WP_038439533.1	D-tyrosyl-tRNA(Tyr) deacylase	-
H733_RS02930	588696..589172	-	477	WP_005661209.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
H733_RS02935	589169..589846	-	678	WP_005655267.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
H733_RS02940	589846..590124	-	279	WP_005665661.1	cell division protein FtsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39935.58 Da
• Isoelectric Point: 6.4335

>T47147 WP_038439531.1 NZ_CP007805:c585235-584204 [Haemophilus influenzae CGSHiCZ412602]
MNFCRILLKPLKKNEALSGYSAEGLHYLTGNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIEDDHFNSINQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVIKRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLVREEGNDTLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLFLLNVLNEPEL

Nucleotide

• Length: 1032 bp

>T47147 NZ_CP007805:c585235-584204 [Haemophilus influenzae CGSHiCZ412602]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTAAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGGCAATAAACATTTTAATCCTGAATTACCTTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCGAAGATGATCACTTTAACAGCATAAATCAACAG
GGAAACTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAAAGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TACGGAAAAATAGGTGCAGATAATGAGCAATATGTGAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACTGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCCTTGCCATTGTTAGTGCGAGAAGAGGGTAATGACACACTAGCCAAAGGATTTAA
TACTCAATACGGCGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAACCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTATTTTTGCTTAACGTATTAAATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12438.06 Da
• Isoelectric Point: 5.8850

>AT47147 WP_020910207.1 NZ_CP007805:c585552-585232 [Haemophilus influenzae CGSHiCZ412602]
MRDLVRSGKVFLYGEFIGLLREDHHGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYAFHQRID
EGDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT47147 NZ_CP007805:c585552-585232 [Haemophilus influenzae CGSHiCZ412602]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGTGAATTTATTGGCTTACTTAGAGAAGATCATCATGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGCCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTAGTCCCAGAAGGCTGGCTAAAACACAAATATGCATTTCATCAACGAATTGAT
GAAGGTGATATGTTTCGCTTTTTACTTAATAATGGTGAAAATATGTTAGGTGCAGTGCAAATTCAGGAGGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A806DF96