47143

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 3777308..3778008 Replicon chromosome
Accession NZ_CP007803
Organism Mycobacterium tuberculosis K

Toxin (Protein)


Gene name vapC Uniprot ID O50411
Locus tag MTBK_RS17735 Protein ID WP_003417916.1
Coordinates 3777308..3777700 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WF13
Locus tag MTBK_RS17740 Protein ID WP_003417918.1
Coordinates 3777700..3778008 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTBK_RS17710 3773155..3773397 - 243 Protein_3496 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MTBK_RS17720 3773450..3774711 + 1262 WP_087902221.1 IS3-like element IS987 family transposase -
MTBK_RS17725 3774750..3775502 - 753 Protein_3498 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
MTBK_RS17730 3775502..3776554 - 1053 WP_003900678.1 polyprenyl synthetase family protein -
MTBK_RS17735 3777308..3777700 - 393 WP_003417916.1 type II toxin-antitoxin system VapC family toxin Toxin
MTBK_RS17740 3777700..3778008 - 309 WP_003417918.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MTBK_RS21705 3778187..3779528 + 1342 Protein_3502 ISNCY family transposase -
MTBK_RS17755 3779718..3780374 + 657 WP_173401023.1 PE family protein -
MTBK_RS22255 3780301..3780537 + 237 WP_009938069.1 hypothetical protein -
MTBK_RS17760 3780583..3781455 - 873 WP_003417929.1 3-hydroxyacyl-thioester dehydratase HtdY -
MTBK_RS17765 3781529..3782239 + 711 WP_003902464.1 phosphoglycerate mutase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside IScluster/Tn - - 3773450..3779528 6078


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(12-64)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14316.74 Da        Isoelectric Point: 10.7249

>T47143 WP_003417916.1 NZ_CP007803:c3777700-3777308 [Mycobacterium tuberculosis K]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSALARAEVMRALLDKGESARKAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMAVIAPS

Download         Length: 393 bp

>T47143 NZ_CP007803:c3777700-3777308 [Mycobacterium tuberculosis K]
ATGGCGGCCATCTATCTCGACTCGTCCGCGATCGTCAAGCTCGCGGTTCGCGAGCCAGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGAGTGTCGAGTGCCCTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAAAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGGCCGTGATCGCCCCGTCGTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11030.59 Da        Isoelectric Point: 4.5332

>AT47143 WP_003417918.1 NZ_CP007803:c3778008-3777700 [Mycobacterium tuberculosis K]
MTPTACATVSTMTSVGVRALRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDVVDLPEP
LDLDAGVELPSVTLARLREHER

Download         Length: 309 bp

>AT47143 NZ_CP007803:c3778008-3777700 [Mycobacterium tuberculosis K]
ATGACGCCGACCGCTTGTGCTACAGTTAGCACAATGACCTCGGTGGGGGTGCGTGCGCTGCGGCAGCGGGCCAGCGAGCT
GCTGCGCCGAGTCGAGGCCGGCGAGACGATCGAGATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGC
AGGGCGGTCCATACGAGCAGCTGCTGGCAAGCGGCGAGATCGAGCGTGCCACGCTCGACGTCGTTGATCTGCCCGAACCG
CTCGACCTCGACGCGGGCGTCGAGCTGCCGTCGGTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BXS8

Antitoxin

Source ID Structure
PDB 6JQY
AlphaFold DB P9WF13

References