Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/-
Location 2957841..2958489 Replicon chromosome
Accession NZ_CP007803
Organism Mycobacterium tuberculosis K

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID P9WJ12
Locus tag MTBK_RS13925 Protein ID WP_003899414.1
Coordinates 2957841..2958164 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID P9WJ10
Locus tag MTBK_RS13930 Protein ID WP_003899415.1
Coordinates 2958244..2958489 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MTBK_RS13895 2953164..2954162 + 999 WP_003900538.1 tyrosine-type recombinase/integrase -
MTBK_RS13900 2954176..2954640 + 465 WP_003900539.1 ParB N-terminal domain-containing protein -
MTBK_RS13905 2954628..2954879 + 252 WP_003908028.1 hypothetical protein -
MTBK_RS13910 2955050..2956489 - 1440 WP_003901443.1 phage major capsid protein -
MTBK_RS13915 2956497..2957030 - 534 WP_003899412.1 HK97 family phage prohead protease -
MTBK_RS21485 2957183..2957809 - 627 WP_003899413.1 phage terminase small subunit P27 family -
MTBK_RS13925 2957841..2958164 - 324 WP_003899414.1 type II toxin-antitoxin system toxin Toxin
MTBK_RS13930 2958244..2958489 - 246 WP_003899415.1 type II toxin-antitoxin system antitoxin Antitoxin
MTBK_RS13935 2958486..2959913 - 1428 WP_003899416.1 DUF3631 domain-containing protein -
MTBK_RS13940 2959915..2960307 - 393 WP_003899417.1 DUF2742 domain-containing protein -
MTBK_RS13945 2960304..2960564 - 261 WP_003899418.1 helix-turn-helix domain-containing protein -
MTBK_RS13950 2960581..2960943 - 363 WP_003900543.1 hypothetical protein -
MTBK_RS13955 2960946..2962073 - 1128 WP_003899420.1 site-specific integrase -
MTBK_RS13960 2962218..2962445 - 228 WP_003899421.1 hypothetical protein -
MTBK_RS21490 2962442..2962831 - 390 WP_003899422.1 hypothetical protein -
MTBK_RS13965 2962737..2963009 + 273 WP_003900544.1 hypothetical protein -
MTBK_RS13970 2963108..2963341 + 234 WP_003413717.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 2953164..2962073 8909


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12359.82 Da        Isoelectric Point: 8.6717

>T47132 WP_003899414.1 NZ_CP007803:c2958164-2957841 [Mycobacterium tuberculosis K]
MTHKRTKRQPAIAAGLNAPRRNRVGRQHGWPADVPSAEQRRAQRQRDLEAIRRAYAEMVATSHEIDDDTAELALLSMHLD
DEQRRLEAGMKLGWHPYHFPDEPDSKQ

Download         Length: 324 bp

>T47132 NZ_CP007803:c2958164-2957841 [Mycobacterium tuberculosis K]
TTGACCCACAAGCGCACTAAACGCCAGCCAGCCATCGCCGCAGGGCTCAACGCCCCGCGTCGGAATCGCGTTGGGCGGCA
ACATGGTTGGCCGGCCGACGTTCCGTCCGCCGAGCAGCGCCGCGCCCAACGGCAGCGCGACCTCGAGGCTATCCGCCGAG
CGTACGCCGAGATGGTGGCGACATCACACGAAATCGACGACGACACAGCCGAACTGGCGCTGTTGTCGATGCATCTCGAC
GATGAGCAGCGCCGGCTTGAGGCGGGGATGAAGCTCGGCTGGCATCCGTATCACTTCCCCGACGAACCCGACAGCAAACA
GTGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 7697.71 Da        Isoelectric Point: 4.8565

>AT47132 WP_003899415.1 NZ_CP007803:c2958489-2958244 [Mycobacterium tuberculosis K]
MSGHALAARTLLAAADELVGGPPVEASAAALAGDAAGAWRTAAVELARALVRAVAESHGVAAVLFAATAAAAAAVDRGDP
P

Download         Length: 246 bp

>AT47132 NZ_CP007803:c2958489-2958244 [Mycobacterium tuberculosis K]
ATGAGCGGCCACGCGTTGGCTGCTCGGACGTTGCTGGCCGCCGCGGACGAGCTTGTCGGCGGCCCGCCAGTCGAGGCTTC
GGCCGCCGCGCTGGCCGGCGACGCCGCGGGCGCATGGCGGACCGCGGCCGTCGAGCTTGCGCGAGCGTTGGTCCGCGCTG
TGGCGGAGTCGCACGGCGTCGCGGCCGTTTTGTTCGCCGCGACGGCCGCCGCGGCGGCGGCCGTCGACCGGGGTGATCCG
CCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A045IHC4

Antitoxin

Source ID Structure
AlphaFold DB A0A806JR81

References