Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 5233970..5234769 Replicon chromosome
Accession NZ_CP007799
Organism Escherichia coli Nissle 1917

Toxin (Protein)


Gene name yhaV Uniprot ID Q8FDB4
Locus tag ECOLIN_RS26080 Protein ID WP_000347252.1
Coordinates 5233970..5234434 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag ECOLIN_RS26085 Protein ID WP_001296435.1
Coordinates 5234434..5234769 (-) Length 112 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ECOLIN_RS26060 5230251..5230493 - 243 Protein_4931 acetyl-CoA carboxylase biotin carboxyl carrier protein -
ECOLIN_RS26065 (ECOLIN_25280) 5230491..5231150 + 660 Protein_4932 glucose PTS transporter subunit EIIB -
ECOLIN_RS26070 (ECOLIN_25285) 5231203..5232663 - 1461 Protein_4933 ferric-rhodotorulic acid/ferric-coprogen receptor FhuE -
ECOLIN_RS29965 5232657..5232773 - 117 Protein_4934 class II D-tagatose-bisphosphate aldolase, non-catalytic subunit -
ECOLIN_RS26075 (ECOLIN_25290) 5233022..5233846 + 825 WP_000072188.1 aga operon transcriptional regulator AgaR -
ECOLIN_RS26080 (ECOLIN_25295) 5233970..5234434 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
ECOLIN_RS26085 (ECOLIN_25300) 5234434..5234769 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
ECOLIN_RS26090 (ECOLIN_25305) 5234918..5235769 - 852 Protein_4938 UxaA family hydrolase -
ECOLIN_RS26095 (ECOLIN_25310) 5235746..5236864 + 1119 WP_128971752.1 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG -
ECOLIN_RS31880 5237055..5237138 + 84 Protein_4940 type II toxin-antitoxin system HigB family toxin -
ECOLIN_RS26100 (ECOLIN_25315) 5237135..5237551 + 417 WP_000560266.1 type II toxin-antitoxin system antitoxin HigA -
ECOLIN_RS26105 (ECOLIN_25320) 5237596..5238330 - 735 Protein_4942 NADPH-dependent 2,4-dienoyl-CoA reductase -
ECOLIN_RS32225 5238576..5238689 - 114 WP_001161660.1 DUF957 domain-containing protein -
ECOLIN_RS26110 (ECOLIN_25325) 5238702..5238908 - 207 WP_128971753.1 hypothetical protein -
ECOLIN_RS26115 (ECOLIN_25330) 5238905..5239279 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA -
ECOLIN_RS26120 (ECOLIN_25335) 5239368..5239736 - 369 WP_038427208.1 type IV toxin-antitoxin system toxin CbtA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-150)

Antitoxin

(14-110)


Sequences


Toxin        


Download         Length: 155 a.a.        Molecular weight: 17750.11 Da        Isoelectric Point: 9.4947

>T47054 WP_000347252.1 NZ_CP007799:c5234434-5233970 [Escherichia coli Nissle 1917]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEESH

Download         Length: 465 bp

>T47054 NZ_CP007799:c5234434-5233970 [Escherichia coli Nissle 1917]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGCGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAGCCATTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT47054 WP_001296435.1 NZ_CP007799:c5234769-5234434 [Escherichia coli Nissle 1917]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT47054 NZ_CP007799:c5234769-5234434 [Escherichia coli Nissle 1917]
ATGCCCGCTAATGCTCGCTCTAACGCTGTACTGACCACTGAATCAAAGGTCACTATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCTGGCCTGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCGACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGACGATGAGAT
TGGCGACGACGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB Q8FDB4


Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References