Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 65736..66435 Replicon chromosome
Accession NZ_CP007784
Organism Burkholderia cenocepacia strain DDS 22E-1

Toxin (Protein)


Gene name mqsR Uniprot ID A0A088UGY6
Locus tag DM39_RS21630 Protein ID WP_040129174.1
Coordinates 66139..66435 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A088UC35
Locus tag DM39_RS21625 Protein ID WP_040129172.1
Coordinates 65736..66137 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM39_RS21610 62544..63896 - 1353 WP_040129167.1 LLM class flavin-dependent oxidoreductase -
DM39_RS21615 63932..64873 - 942 WP_040129168.1 ABC transporter substrate-binding protein -
DM39_RS21620 64927..65487 - 561 WP_040129170.1 GNAT family N-acetyltransferase -
DM39_RS21625 65736..66137 - 402 WP_040129172.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
DM39_RS21630 66139..66435 - 297 WP_040129174.1 type II toxin-antitoxin system MqsR family toxin Toxin
DM39_RS21635 66554..67588 - 1035 WP_040129175.1 succinylglutamate desuccinylase/aspartoacylase family protein -
DM39_RS21640 67742..68014 - 273 WP_009688345.1 hypothetical protein -
DM39_RS21645 68242..69789 - 1548 WP_040129176.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11264.14 Da        Isoelectric Point: 9.5731

>T47008 WP_040129174.1 NZ_CP007784:c66435-66139 [Burkholderia cenocepacia]
MEKRTPHCKLPRVKALIEAGKVRLTASAVIGARQMGFTEAETIDVVRALTPFEFHKSMTTYADHTIWQDVYRPWTLRGDV
YLKLTVVDDVLIVSFKER

Download         Length: 297 bp

>T47008 NZ_CP007784:c66435-66139 [Burkholderia cenocepacia]
ATGGAAAAGAGAACGCCGCACTGCAAGCTGCCGCGCGTCAAGGCGCTGATCGAGGCCGGCAAGGTCCGCCTGACCGCAAG
CGCCGTCATCGGCGCCCGCCAGATGGGCTTCACCGAAGCGGAAACGATCGACGTGGTGAGGGCGCTGACGCCGTTCGAAT
TCCACAAGAGCATGACGACCTACGCCGACCACACGATCTGGCAGGACGTCTACCGGCCTTGGACGCTGCGCGGCGACGTG
TACCTGAAACTGACCGTCGTCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14554.75 Da        Isoelectric Point: 7.6342

>AT47008 WP_040129172.1 NZ_CP007784:c66137-65736 [Burkholderia cenocepacia]
MKCPACGAATLIRDTRDIPYTYKGESTVIPRITGEFCPACGESVLDVDEATRFGEAVSAFNRQVNATLVDPKFIATVRKK
LKLDQREAAEIFGGGVNAFSRYETGKTNPPLALVKLLKILDRHPDLLDEVRAA

Download         Length: 402 bp

>AT47008 NZ_CP007784:c66137-65736 [Burkholderia cenocepacia]
ATGAAATGTCCTGCATGCGGTGCCGCCACGCTGATCCGCGACACGCGCGACATCCCGTACACCTACAAGGGCGAATCGAC
CGTGATCCCGCGCATCACGGGCGAGTTTTGTCCCGCGTGCGGCGAGTCGGTGCTCGACGTCGACGAGGCGACCCGTTTCG
GCGAAGCGGTGTCGGCGTTCAACCGGCAAGTGAACGCGACGCTCGTCGATCCGAAGTTCATTGCGACGGTACGCAAGAAG
CTGAAGCTCGATCAGCGCGAGGCGGCCGAGATTTTCGGCGGCGGCGTCAACGCGTTTTCCCGCTACGAGACCGGCAAGAC
CAATCCGCCGCTGGCGCTGGTGAAGCTGCTGAAGATCCTCGACCGTCATCCGGACCTGCTCGACGAAGTGCGCGCGGCAT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A088UGY6

Antitoxin

Source ID Structure
AlphaFold DB A0A088UC35

References