Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-YefM
Location 2369173..2369675 Replicon chromosome
Accession NZ_CP007757
Organism Halomonas campaniensis strain LS21

Toxin (Protein)


Gene name yoeB Uniprot ID A0A060B802
Locus tag FF32_RS10455 Protein ID WP_038482190.1
Coordinates 2369412..2369675 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID F7SL01
Locus tag FF32_RS10450 Protein ID WP_009722422.1
Coordinates 2369173..2369415 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FF32_RS10420 2364436..2365134 - 699 WP_038482178.1 thiaminase II -
FF32_RS10425 2365621..2366130 + 510 WP_051626555.1 hypothetical protein -
FF32_RS18770 2366988..2367666 - 679 Protein_2066 transposase -
FF32_RS10440 2367836..2368177 + 342 WP_038482187.1 hypothetical protein -
FF32_RS10445 2368177..2368911 + 735 Protein_2068 hypothetical protein -
FF32_RS18775 2368924..2369028 + 105 Protein_2069 addiction module antidote protein, HigA family -
FF32_RS10450 2369173..2369415 + 243 WP_009722422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
FF32_RS10455 2369412..2369675 + 264 WP_038482190.1 Txe/YoeB family addiction module toxin Toxin
FF32_RS10460 2369812..2370633 - 822 WP_038482193.1 aldo/keto reductase -
FF32_RS10465 2370789..2371349 - 561 WP_038482196.1 manganese efflux pump MntP family protein -
FF32_RS10470 2371850..2372596 - 747 WP_038482199.1 CDP-alcohol phosphatidyltransferase family protein -
FF32_RS10475 2372809..2373798 + 990 WP_038482202.1 zinc-binding alcohol dehydrogenase -
FF32_RS10480 2373876..2374274 + 399 WP_009722429.1 6-carboxytetrahydropterin synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10068.68 Da        Isoelectric Point: 9.3418

>T46995 WP_038482190.1 NZ_CP007757:2369412-2369675 [Halomonas campaniensis]
VTWTLVYTKQAQKDAEKLASSGLKPKAQELLALIAEDPYRKPPPFEKLIGDLTGAYSRRINIQHRLVYQVLEDEQVVKVL
RLWSLYE

Download         Length: 264 bp

>T46995 NZ_CP007757:2369412-2369675 [Halomonas campaniensis]
GTGACATGGACGTTGGTTTACACCAAACAAGCCCAGAAGGACGCAGAGAAGCTGGCTTCAAGCGGCCTCAAGCCAAAAGC
CCAAGAGTTGTTGGCCCTAATTGCAGAAGATCCGTACCGCAAGCCGCCCCCGTTTGAGAAGCTCATTGGTGATCTTACGG
GCGCCTATTCACGCCGCATCAATATCCAGCATCGGTTGGTCTACCAAGTGCTAGAAGACGAGCAAGTAGTGAAAGTCCTC
AGGCTATGGAGCCTCTACGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9075.15 Da        Isoelectric Point: 4.0066

>AT46995 WP_009722422.1 NZ_CP007757:2369173-2369415 [Halomonas campaniensis]
MTGITATEARSNLYRLIDETAESHQPIVIMGKRNKAVLVSEEDWSAIQETLYLLSVPGMRESIREGMDTSVDECDEELDW

Download         Length: 243 bp

>AT46995 NZ_CP007757:2369173-2369415 [Halomonas campaniensis]
ATGACTGGAATCACAGCAACGGAGGCGCGGAGCAACCTTTATCGGTTGATTGACGAGACCGCCGAGTCCCACCAACCCAT
CGTCATCATGGGTAAGCGGAACAAAGCCGTCCTGGTTTCCGAGGAAGACTGGTCCGCCATTCAGGAAACCCTTTACCTGC
TTTCCGTACCGGGTATGCGGGAGTCTATTCGTGAGGGAATGGATACCTCCGTGGATGAGTGCGATGAGGAGCTGGACTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060B802

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2DG95

References