Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 626819..627434 Replicon chromosome
Accession NZ_CP007748
Organism Burkholderia cepacia ATCC 25416

Toxin (Protein)


Gene name higB Uniprot ID A0A806VP16
Locus tag DM41_RS27515 Protein ID WP_027789973.1
Coordinates 626819..627160 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A806UZQ0
Locus tag DM41_RS27520 Protein ID WP_027789974.1
Coordinates 627147..627434 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DM41_RS27505 623904..625541 - 1638 WP_027789971.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -
DM41_RS27510 625971..626603 + 633 WP_027789972.1 LysE family translocator -
DM41_RS27515 626819..627160 + 342 WP_027789973.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DM41_RS27520 627147..627434 + 288 WP_027789974.1 helix-turn-helix transcriptional regulator Antitoxin
DM41_RS27525 627514..628203 - 690 WP_027789975.1 YebB family permuted papain-like enzyme -
DM41_RS27530 628383..628952 - 570 WP_027789976.1 hypothetical protein -
DM41_RS27535 629173..629631 - 459 WP_006749370.1 Lrp/AsnC family transcriptional regulator -
DM41_RS27540 629758..630492 + 735 WP_027789977.1 AzlC family ABC transporter permease -
DM41_RS27545 630485..630793 + 309 WP_027789978.1 AzlD family protein -
DM41_RS27550 631112..631891 + 780 WP_027789979.1 5'/3'-nucleotidase SurE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(21-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-90)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13112.25 Da        Isoelectric Point: 9.5171

>T46985 WP_027789973.1 NZ_CP007748:626819-627160 [Burkholderia cepacia ATCC 25416]
MRTVADEIHFFSEQVEAGVFALPKTLIARFFALADRMEQYGPNPGEPHTRPMGDGLYEMRLKGLEDIARVFYCAVVNRRI
VMLHCYVKKTQKTPQKDLETARRRLKEIRDGNL

Download         Length: 342 bp

>T46985 NZ_CP007748:626819-627160 [Burkholderia cepacia ATCC 25416]
ATGCGAACCGTCGCGGATGAAATCCATTTCTTCAGCGAGCAAGTCGAGGCTGGCGTATTTGCGTTGCCGAAAACGCTGAT
CGCCAGATTCTTCGCACTCGCTGACCGCATGGAGCAGTACGGCCCGAATCCGGGCGAACCTCACACCAGGCCGATGGGCG
ACGGGTTGTACGAAATGCGGTTGAAGGGCCTGGAAGATATCGCACGTGTGTTTTACTGCGCGGTCGTCAACCGGCGGATC
GTCATGCTTCACTGCTACGTGAAGAAGACGCAGAAAACGCCGCAGAAGGACCTGGAAACCGCGCGCCGCCGATTGAAGGA
GATTCGAGATGGCAACCTATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10296.90 Da        Isoelectric Point: 9.6540

>AT46985 WP_027789974.1 NZ_CP007748:627147-627434 [Burkholderia cepacia ATCC 25416]
MATYKALRERALADPTVCAEYDRLNREEFALLDAMLAARRAAGLSQADVAERMGTKAPAVTRLERALATGQHSPSIDTLR
KYAAACGKKLVISFA

Download         Length: 288 bp

>AT46985 NZ_CP007748:627147-627434 [Burkholderia cepacia ATCC 25416]
ATGGCAACCTATAAGGCACTGCGCGAGCGCGCGTTGGCCGATCCGACGGTATGCGCCGAGTACGACCGGCTGAACCGCGA
GGAATTCGCGCTGCTCGACGCAATGCTGGCCGCCCGGCGAGCCGCCGGTCTTTCGCAAGCCGATGTGGCAGAGCGCATGG
GCACGAAGGCGCCTGCCGTCACGCGGCTCGAACGTGCGCTCGCGACAGGCCAGCACTCGCCGTCGATTGATACGCTGCGC
AAGTATGCGGCCGCATGCGGCAAGAAACTCGTGATCTCTTTCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806VP16

Antitoxin

Source ID Structure
AlphaFold DB A0A806UZQ0

References