Detailed information of TA system TA046980

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 4899372..4900029
• Replicon: chromosome
• Accession: NZ_CP007744
• Organism: Pectobacterium atrosepticum strain JG10-08

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: EV46_RS21550
• Protein ID: WP_039294444.1
• Coordinates: 4899372..4899743 (+)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: EV46_RS21555
• Protein ID: WP_039294447.1
• Coordinates: 4899730..4900029 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EV46_RS21525	4894475..4895623	-	1149	WP_039294433.1	galactonate dehydratase	-
EV46_RS21530	4895620..4896237	-	618	WP_039294435.1	2-dehydro-3-deoxy-6-phosphogalactonate aldolase	-
EV46_RS21535	4896221..4897117	-	897	WP_039294438.1	2-dehydro-3-deoxygalactonokinase	-
EV46_RS21540	4897114..4897811	-	698	Protein_4247	D-galactonate utilization transcriptional regulator DgoR	-
EV46_RS21545	4898169..4899200	-	1032	WP_039289737.1	IS630-like element ISPeat1 family transposase	-
EV46_RS21550	4899372..4899743	+	372	WP_039294444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
EV46_RS21555	4899730..4900029	+	300	WP_039294447.1	XRE family transcriptional regulator	Antitoxin
EV46_RS21560	4900067..4901866	-	1800	WP_039294450.1	ABC transporter ATP-binding protein	-
EV46_RS21565	4901906..4902814	-	909	WP_039294453.1	ABC transporter permease	-
EV46_RS21570	4902811..4903788	-	978	WP_039294455.1	ABC transporter permease	-
EV46_RS21575	4903788..4904759	-	972	WP_039294457.1	nucleoside hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4898169..4899200	1031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (14-108)

Antitoxin

• Cro/C1-type helix-turn-helix domain (32-80)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 14160.08 Da
• Isoelectric Point: 4.8590

>T46980 WP_039294444.1 NZ_CP007744:4899372-4899743 [Pectobacterium atrosepticum]
MAWKIVTRDLFDTWFDEQTEAVQEEVLAHLAILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFDRTRKA
IVLCAGDKKGEDEKLFYERMIKIADAEFTSHLISPEVKEDGDA

Nucleotide

• Length: 372 bp

>T46980 NZ_CP007744:4899372-4899743 [Pectobacterium atrosepticum]
TTGGCATGGAAAATAGTAACACGGGATCTATTCGATACTTGGTTTGATGAGCAAACCGAAGCGGTACAGGAAGAGGTTTT
GGCACACCTCGCAATACTCGAAGAGGATGGCCCACAGCTAGGACGACCACAGGTTGATCAGATTAAAGGTTCAAAATACA
AAAATATGAAGGAGCTGCGGGTTCAGGTTGGAGGCCACCCATTCCGAACATTCTTCGCGTTTGACCGGACACGTAAAGCG
ATTGTTTTATGTGCAGGAGATAAGAAAGGCGAGGATGAAAAATTGTTCTACGAACGTATGATTAAGATCGCAGACGCTGA
GTTTACATCGCATCTGATATCACCGGAGGTAAAAGAAGATGGCGACGCTTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11019.09 Da
• Isoelectric Point: 10.8728

>AT46980 WP_039294447.1 NZ_CP007744:4899730-4900029 [Pectobacterium atrosepticum]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELKMSQTQLAAALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPNGKRIALTL

Nucleotide

• Length: 300 bp

>AT46980 NZ_CP007744:4899730-4900029 [Pectobacterium atrosepticum]
ATGGCGACGCTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGTGCCCGTATTGAGGCGCGCACGGCTGAGATCCG
CCAGGAAATCACTTTAGCGAAACTACGCGAAGAACTGAAAATGTCGCAGACGCAGCTTGCAGCAGCATTGGGGGTCAAGC
AGCCATCTATTGTTAAGATGGAAAAGGTTGAAAATGACCCAAAACTGTCAACGCTGAAACGCTATGTAACTGCCCTAGGC
GGTAAGCTTACGCTAGATGTGACCCTACCTAATGGTAAGCGTATCGCGCTTACGTTGTAA