Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4899372..4900029 Replicon chromosome
Accession NZ_CP007744
Organism Pectobacterium atrosepticum strain JG10-08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag EV46_RS21550 Protein ID WP_039294444.1
Coordinates 4899372..4899743 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag EV46_RS21555 Protein ID WP_039294447.1
Coordinates 4899730..4900029 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EV46_RS21525 4894475..4895623 - 1149 WP_039294433.1 galactonate dehydratase -
EV46_RS21530 4895620..4896237 - 618 WP_039294435.1 2-dehydro-3-deoxy-6-phosphogalactonate aldolase -
EV46_RS21535 4896221..4897117 - 897 WP_039294438.1 2-dehydro-3-deoxygalactonokinase -
EV46_RS21540 4897114..4897811 - 698 Protein_4247 D-galactonate utilization transcriptional regulator DgoR -
EV46_RS21545 4898169..4899200 - 1032 WP_039289737.1 IS630-like element ISPeat1 family transposase -
EV46_RS21550 4899372..4899743 + 372 WP_039294444.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
EV46_RS21555 4899730..4900029 + 300 WP_039294447.1 XRE family transcriptional regulator Antitoxin
EV46_RS21560 4900067..4901866 - 1800 WP_039294450.1 ABC transporter ATP-binding protein -
EV46_RS21565 4901906..4902814 - 909 WP_039294453.1 ABC transporter permease -
EV46_RS21570 4902811..4903788 - 978 WP_039294455.1 ABC transporter permease -
EV46_RS21575 4903788..4904759 - 972 WP_039294457.1 nucleoside hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4898169..4899200 1031


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-80)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 14160.08 Da        Isoelectric Point: 4.8590

>T46980 WP_039294444.1 NZ_CP007744:4899372-4899743 [Pectobacterium atrosepticum]
MAWKIVTRDLFDTWFDEQTEAVQEEVLAHLAILEEDGPQLGRPQVDQIKGSKYKNMKELRVQVGGHPFRTFFAFDRTRKA
IVLCAGDKKGEDEKLFYERMIKIADAEFTSHLISPEVKEDGDA

Download         Length: 372 bp

>T46980 NZ_CP007744:4899372-4899743 [Pectobacterium atrosepticum]
TTGGCATGGAAAATAGTAACACGGGATCTATTCGATACTTGGTTTGATGAGCAAACCGAAGCGGTACAGGAAGAGGTTTT
GGCACACCTCGCAATACTCGAAGAGGATGGCCCACAGCTAGGACGACCACAGGTTGATCAGATTAAAGGTTCAAAATACA
AAAATATGAAGGAGCTGCGGGTTCAGGTTGGAGGCCACCCATTCCGAACATTCTTCGCGTTTGACCGGACACGTAAAGCG
ATTGTTTTATGTGCAGGAGATAAGAAAGGCGAGGATGAAAAATTGTTCTACGAACGTATGATTAAGATCGCAGACGCTGA
GTTTACATCGCATCTGATATCACCGGAGGTAAAAGAAGATGGCGACGCTTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11019.09 Da        Isoelectric Point: 10.8728

>AT46980 WP_039294447.1 NZ_CP007744:4899730-4900029 [Pectobacterium atrosepticum]
MATLKEMMAKRSPESRARIEARTAEIRQEITLAKLREELKMSQTQLAAALGVKQPSIVKMEKVENDPKLSTLKRYVTALG
GKLTLDVTLPNGKRIALTL

Download         Length: 300 bp

>AT46980 NZ_CP007744:4899730-4900029 [Pectobacterium atrosepticum]
ATGGCGACGCTTAAAGAAATGATGGCTAAACGTTCACCGGAGAGCCGTGCCCGTATTGAGGCGCGCACGGCTGAGATCCG
CCAGGAAATCACTTTAGCGAAACTACGCGAAGAACTGAAAATGTCGCAGACGCAGCTTGCAGCAGCATTGGGGGTCAAGC
AGCCATCTATTGTTAAGATGGAAAAGGTTGAAAATGACCCAAAACTGTCAACGCTGAAACGCTATGTAACTGCCCTAGGC
GGTAAGCTTACGCTAGATGTGACCCTACCTAATGGTAAGCGTATCGCGCTTACGTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References