46901

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2555578..2555762 Replicon chromosome
Accession NZ_CP007690
Organism Staphylococcus aureus strain UA-S391_USA300 isolate abscess/wound isolate

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag EX97_RS13155 Protein ID WP_000482650.1
Coordinates 2555655..2555762 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2555578..2555638 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EX97_RS13130 2551108..2551275 - 168 WP_001790576.1 hypothetical protein -
EX97_RS13140 2551506..2553239 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
EX97_RS13145 2553264..2555027 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2555578..2555638 + 61 - - Antitoxin
EX97_RS13155 2555655..2555762 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
EX97_RS13160 2555896..2556282 - 387 WP_000779358.1 flippase GtxA -
EX97_RS13165 2556550..2557692 + 1143 WP_001176863.1 glycerate kinase -
EX97_RS13170 2557752..2558411 + 660 WP_000831298.1 membrane protein -
EX97_RS13175 2558593..2559804 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
EX97_RS13180 2559927..2560400 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T46901 WP_000482650.1 NZ_CP007690:c2555762-2555655 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T46901 NZ_CP007690:c2555762-2555655 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT46901 NZ_CP007690:2555578-2555638 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References