46900

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2530230..2530747 Replicon chromosome
Accession NZ_CP007690
Organism Staphylococcus aureus strain UA-S391_USA300 isolate abscess/wound isolate

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag EX97_RS13000 Protein ID WP_000113262.1
Coordinates 2530230..2530496 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag EX97_RS13005 Protein ID WP_000584502.1
Coordinates 2530496..2530747 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EX97_RS12975 2525656..2526192 - 537 WP_000169317.1 GNAT family N-acetyltransferase -
EX97_RS12980 2526425..2527249 - 825 WP_000572040.1 formate/nitrite transporter family protein -
EX97_RS12985 2527466..2527648 - 183 WP_000230294.1 hypothetical protein -
EX97_RS12990 2527732..2528199 - 468 WP_000153344.1 SRPBCC domain-containing protein -
EX97_RS12995 2528385..2529935 - 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
EX97_RS15605 2530124..2530195 - 72 Protein_2467 hypothetical protein -
EX97_RS13000 2530230..2530496 - 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
EX97_RS13005 2530496..2530747 - 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
EX97_RS13010 2530912..2531013 - 102 WP_001791744.1 hypothetical protein -
EX97_RS13015 2531020..2531619 - 600 WP_000162813.1 DsbA family protein -
EX97_RS13020 2531638..2531997 - 360 WP_000819847.1 DUF4467 domain-containing protein -
EX97_RS13025 2532252..2533502 + 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
EX97_RS13030 2533599..2534330 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
EX97_RS13035 2534327..2535046 - 720 WP_000479576.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T46900 WP_000113262.1 NZ_CP007690:c2530496-2530230 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T46900 NZ_CP007690:c2530496-2530230 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT46900 WP_000584502.1 NZ_CP007690:c2530747-2530496 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT46900 NZ_CP007690:c2530747-2530496 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGTTATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References