Detailed information of TA system TA046898

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2265477..2265740
• Replicon: chromosome
• Accession: NZ_CP007690
• Organism: Staphylococcus aureus strain UA-S391_USA300 isolate abscess/wound isolate

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: EX97_RS11585
• Protein ID: WP_001802298.1
• Coordinates: 2265636..2265740 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	2265477..2265641 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EX97_RS11565	2261660..2262325	-	666	WP_001024094.1	SDR family oxidoreductase	-
EX97_RS11570	2262477..2262797	+	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
EX97_RS11575	2262799..2263779	+	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
EX97_RS11580	2264045..2265136	+	1092	WP_000495671.1	lytic regulatory protein	-
-	2265477..2265641	+	165	-	-	Antitoxin
EX97_RS11585	2265636..2265740	-	105	WP_001802298.1	hypothetical protein	Toxin
EX97_RS15595	2265901..2266384	-	484	Protein_2201	recombinase family protein	-
EX97_RS11595	2266427..2267563	-	1137	WP_000115564.1	SAP domain-containing protein	-
EX97_RS11600	2267852..2267944	+	93	WP_001790138.1	hypothetical protein	-
EX97_RS11605	2268649..2269506	-	858	WP_000370924.1	Cof-type HAD-IIB family hydrolase	-
EX97_RS11610	2269574..2270356	-	783	WP_000908176.1	ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (5-80)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T46898 WP_001802298.1 NZ_CP007690:c2265740-2265636 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T46898 NZ_CP007690:c2265740-2265636 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT46898 NZ_CP007690:2265477-2265641 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin