Detailed information of TA system TA046889

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprA1-sprA1AS/-
• Location: 1929864..1930046
• Replicon: chromosome
• Accession: NZ_CP007690
• Organism: Staphylococcus aureus strain UA-S391_USA300 isolate abscess/wound isolate

Toxin (Protein)

• Gene name: sprA1
• Uniprot ID: -
• Locus tag: EX97_RS15570
• Protein ID: WP_001801861.1
• Coordinates: 1929864..1929959 (+)
• Length: 32 a.a.

Antitoxin (RNA)

Gene name	sprA1AS
Locus tag	-
Coordinates	1929987..1930046 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EX97_RS09545	1925524..1926150	+	627	Protein_1841	hypothetical protein	-
EX97_RS09550	1926191..1926535	+	345	WP_000627551.1	DUF3969 family protein	-
EX97_RS09555	1926633..1927184	+	552	WP_000414205.1	hypothetical protein	-
EX97_RS09560	1927402..1928043	-	642	WP_000494956.1	ImmA/IrrE family metallo-endopeptidase	-
EX97_RS09565	1928157..1928342	-	186	WP_000809857.1	hypothetical protein	-
EX97_RS09570	1928344..1928520	-	177	WP_000375476.1	hypothetical protein	-
EX97_RS09575	1928531..1928914	-	384	WP_000070811.1	hypothetical protein	-
EX97_RS09585	1929518..1929661	-	144	WP_001549059.1	transposase	-
EX97_RS15570	1929864..1929959	+	96	WP_001801861.1	type I toxin-antitoxin system Fst family toxin PepA1	Toxin
-	1929987..1930046	-	60	-	-	Antitoxin
EX97_RS09590	1930082..1930183	+	102	WP_001791893.1	hypothetical protein	-
EX97_RS15200	1930161..1930337	-	177	Protein_1851	transposase	-
EX97_RS09595	1930531..1930908	-	378	WP_001037045.1	DUF1433 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1922964..1948566	25602

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 32 a.a.
• Molecular weight: 3554.32 Da
• Isoelectric Point: 10.4449

>T46889 WP_001801861.1 NZ_CP007690:1929864-1929959 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Nucleotide

• Length: 96 bp

>T46889 NZ_CP007690:1929864-1929959 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin

Nucleotide

• Length: 60 bp

>AT46889 NZ_CP007690:c1930046-1929987 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Structures

Antitoxin