Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2524901..2525085 Replicon chromosome
Accession NZ_CP007676
Organism Staphylococcus aureus strain HUV05

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag ER12_RS12985 Protein ID WP_000482650.1
Coordinates 2524978..2525085 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2524901..2524961 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER12_RS12960 2520431..2520598 - 168 WP_001790576.1 hypothetical protein -
ER12_RS12970 2520829..2522562 - 1734 WP_000486494.1 ABC transporter ATP-binding protein/permease -
ER12_RS12975 2522587..2524350 - 1764 WP_001064838.1 ABC transporter ATP-binding protein/permease -
- 2524901..2524961 + 61 - - Antitoxin
ER12_RS12985 2524978..2525085 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
ER12_RS12990 2525219..2525605 - 387 WP_000779358.1 flippase GtxA -
ER12_RS12995 2525873..2527015 + 1143 WP_047212331.1 glycerate kinase -
ER12_RS13000 2527075..2527734 + 660 WP_000831298.1 membrane protein -
ER12_RS13005 2527916..2529127 + 1212 WP_001192075.1 multidrug effflux MFS transporter -
ER12_RS13010 2529250..2529723 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T46883 WP_000482650.1 NZ_CP007676:c2525085-2524978 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T46883 NZ_CP007676:c2525085-2524978 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 61 bp

>AT46883 NZ_CP007676:2524901-2524961 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References