Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprG-sprF/-
Location 2234866..2235129 Replicon chromosome
Accession NZ_CP007676
Organism Staphylococcus aureus strain HUV05

Toxin (Protein)


Gene name SprG3 Uniprot ID Q2FWA7
Locus tag ER12_RS11410 Protein ID WP_001802298.1
Coordinates 2235025..2235129 (-) Length 35 a.a.

Antitoxin (RNA)


Gene name SprF4
Locus tag -
Coordinates 2234866..2235030 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER12_RS11390 2231049..2231714 - 666 WP_001024094.1 SDR family oxidoreductase -
ER12_RS11395 2231866..2232186 + 321 WP_000003759.1 Zn(II)-responsive metalloregulatory transcriptional repressor CzrA -
ER12_RS11400 2232188..2233168 + 981 WP_000019744.1 CDF family zinc efflux transporter CzrB -
ER12_RS11405 2233434..2234525 + 1092 WP_000495671.1 lytic regulatory protein -
- 2234866..2235030 + 165 - - Antitoxin
ER12_RS11410 2235025..2235129 - 105 WP_001802298.1 hypothetical protein Toxin
ER12_RS15810 2235290..2235773 - 484 Protein_2161 recombinase family protein -
ER12_RS11420 2235816..2236952 - 1137 WP_000115564.1 SAP domain-containing protein -
ER12_RS11425 2237241..2237333 + 93 WP_001790138.1 hypothetical protein -
ER12_RS11430 2238038..2238895 - 858 WP_000370924.1 Cof-type HAD-IIB family hydrolase -
ER12_RS11435 2238963..2239745 - 783 WP_000908176.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 35 a.a.        Molecular weight: 3906.77 Da        Isoelectric Point: 5.5724

>T46880 WP_001802298.1 NZ_CP007676:c2235129-2235025 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Download         Length: 105 bp

>T46880 NZ_CP007676:c2235129-2235025 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTTATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 165 bp

>AT46880 NZ_CP007676:2234866-2235030 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCATTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y9L9

Antitoxin

Download structure file

References